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Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis
OBJECTIVES: To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS). METHODS: MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included: 1) studies a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Masson SAS.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566345/ https://www.ncbi.nlm.nih.gov/pubmed/34836608 http://dx.doi.org/10.1016/j.neurol.2021.10.003 |
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author | Etemadifar, M. Nouri, H. Maracy, M.R. Akhavan Sigari, A. Salari, M. Blanco, Y. Sepúlveda, M. Zabalza, A. Mahdavi, S. Baratian, M. Sedaghat, N. |
author_facet | Etemadifar, M. Nouri, H. Maracy, M.R. Akhavan Sigari, A. Salari, M. Blanco, Y. Sepúlveda, M. Zabalza, A. Mahdavi, S. Baratian, M. Sedaghat, N. |
author_sort | Etemadifar, M. |
collection | PubMed |
description | OBJECTIVES: To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS). METHODS: MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included: 1) studies assessing COVID-19 severity among adult pwMS; 2) definitive diagnoses or high clinical suspicion of COVID-19; 3) a categorization of COVID-19 severity into at least two categories; 4) quantitative effect size and precision measurements; and 5) English language; and 6) clear effect size/precision measures. internal validity of studies was assessed using the NIH Quality Assessment Tools. A list of possible risk factors was created based on the search results and was later used in extraction, synthesis, and meta-analysis of the data. RESULTS: Thirteen studies were included in the syntheses. Outcome measures were either extracted from the papers, obtained from the primary researchers or calculated manually. The meta-analyses showed a significantly (P < 0.05) increased odds of a severe COVID-19 in pwMS with all of the assessed risk factors, except smoking and most DMTs. CONCLUSION: This study facilitates evidence-based risk/benefit assessments in practice. Older men with progressive MS on anti-CD20 therapies are more at risk of an unfortunate COVID-19 outcome. |
format | Online Article Text |
id | pubmed-8566345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85663452021-11-04 Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis Etemadifar, M. Nouri, H. Maracy, M.R. Akhavan Sigari, A. Salari, M. Blanco, Y. Sepúlveda, M. Zabalza, A. Mahdavi, S. Baratian, M. Sedaghat, N. Rev Neurol (Paris) Original Article OBJECTIVES: To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS). METHODS: MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included: 1) studies assessing COVID-19 severity among adult pwMS; 2) definitive diagnoses or high clinical suspicion of COVID-19; 3) a categorization of COVID-19 severity into at least two categories; 4) quantitative effect size and precision measurements; and 5) English language; and 6) clear effect size/precision measures. internal validity of studies was assessed using the NIH Quality Assessment Tools. A list of possible risk factors was created based on the search results and was later used in extraction, synthesis, and meta-analysis of the data. RESULTS: Thirteen studies were included in the syntheses. Outcome measures were either extracted from the papers, obtained from the primary researchers or calculated manually. The meta-analyses showed a significantly (P < 0.05) increased odds of a severe COVID-19 in pwMS with all of the assessed risk factors, except smoking and most DMTs. CONCLUSION: This study facilitates evidence-based risk/benefit assessments in practice. Older men with progressive MS on anti-CD20 therapies are more at risk of an unfortunate COVID-19 outcome. Elsevier Masson SAS. 2022 2021-11-04 /pmc/articles/PMC8566345/ /pubmed/34836608 http://dx.doi.org/10.1016/j.neurol.2021.10.003 Text en © 2021 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Etemadifar, M. Nouri, H. Maracy, M.R. Akhavan Sigari, A. Salari, M. Blanco, Y. Sepúlveda, M. Zabalza, A. Mahdavi, S. Baratian, M. Sedaghat, N. Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis |
title | Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis |
title_full | Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis |
title_fullStr | Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis |
title_full_unstemmed | Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis |
title_short | Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis |
title_sort | risk factors of severe covid-19 in people with multiple sclerosis : a systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566345/ https://www.ncbi.nlm.nih.gov/pubmed/34836608 http://dx.doi.org/10.1016/j.neurol.2021.10.003 |
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