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Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis

OBJECTIVES: To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS). METHODS: MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included: 1) studies a...

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Autores principales: Etemadifar, M., Nouri, H., Maracy, M.R., Akhavan Sigari, A., Salari, M., Blanco, Y., Sepúlveda, M., Zabalza, A., Mahdavi, S., Baratian, M., Sedaghat, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566345/
https://www.ncbi.nlm.nih.gov/pubmed/34836608
http://dx.doi.org/10.1016/j.neurol.2021.10.003
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author Etemadifar, M.
Nouri, H.
Maracy, M.R.
Akhavan Sigari, A.
Salari, M.
Blanco, Y.
Sepúlveda, M.
Zabalza, A.
Mahdavi, S.
Baratian, M.
Sedaghat, N.
author_facet Etemadifar, M.
Nouri, H.
Maracy, M.R.
Akhavan Sigari, A.
Salari, M.
Blanco, Y.
Sepúlveda, M.
Zabalza, A.
Mahdavi, S.
Baratian, M.
Sedaghat, N.
author_sort Etemadifar, M.
collection PubMed
description OBJECTIVES: To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS). METHODS: MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included: 1) studies assessing COVID-19 severity among adult pwMS; 2) definitive diagnoses or high clinical suspicion of COVID-19; 3) a categorization of COVID-19 severity into at least two categories; 4) quantitative effect size and precision measurements; and 5) English language; and 6) clear effect size/precision measures. internal validity of studies was assessed using the NIH Quality Assessment Tools. A list of possible risk factors was created based on the search results and was later used in extraction, synthesis, and meta-analysis of the data. RESULTS: Thirteen studies were included in the syntheses. Outcome measures were either extracted from the papers, obtained from the primary researchers or calculated manually. The meta-analyses showed a significantly (P < 0.05) increased odds of a severe COVID-19 in pwMS with all of the assessed risk factors, except smoking and most DMTs. CONCLUSION: This study facilitates evidence-based risk/benefit assessments in practice. Older men with progressive MS on anti-CD20 therapies are more at risk of an unfortunate COVID-19 outcome.
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spelling pubmed-85663452021-11-04 Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis Etemadifar, M. Nouri, H. Maracy, M.R. Akhavan Sigari, A. Salari, M. Blanco, Y. Sepúlveda, M. Zabalza, A. Mahdavi, S. Baratian, M. Sedaghat, N. Rev Neurol (Paris) Original Article OBJECTIVES: To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS). METHODS: MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included: 1) studies assessing COVID-19 severity among adult pwMS; 2) definitive diagnoses or high clinical suspicion of COVID-19; 3) a categorization of COVID-19 severity into at least two categories; 4) quantitative effect size and precision measurements; and 5) English language; and 6) clear effect size/precision measures. internal validity of studies was assessed using the NIH Quality Assessment Tools. A list of possible risk factors was created based on the search results and was later used in extraction, synthesis, and meta-analysis of the data. RESULTS: Thirteen studies were included in the syntheses. Outcome measures were either extracted from the papers, obtained from the primary researchers or calculated manually. The meta-analyses showed a significantly (P < 0.05) increased odds of a severe COVID-19 in pwMS with all of the assessed risk factors, except smoking and most DMTs. CONCLUSION: This study facilitates evidence-based risk/benefit assessments in practice. Older men with progressive MS on anti-CD20 therapies are more at risk of an unfortunate COVID-19 outcome. Elsevier Masson SAS. 2022 2021-11-04 /pmc/articles/PMC8566345/ /pubmed/34836608 http://dx.doi.org/10.1016/j.neurol.2021.10.003 Text en © 2021 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Etemadifar, M.
Nouri, H.
Maracy, M.R.
Akhavan Sigari, A.
Salari, M.
Blanco, Y.
Sepúlveda, M.
Zabalza, A.
Mahdavi, S.
Baratian, M.
Sedaghat, N.
Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis
title Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis
title_full Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis
title_fullStr Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis
title_full_unstemmed Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis
title_short Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis
title_sort risk factors of severe covid-19 in people with multiple sclerosis : a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566345/
https://www.ncbi.nlm.nih.gov/pubmed/34836608
http://dx.doi.org/10.1016/j.neurol.2021.10.003
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