BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors

Adenine and cytosine base editors (ABE, CBE) allow for precision genome engineering. Here, Base Editor Activity Reporter (BEAR), a plasmid-based fluorescent tool is introduced, which can be applied to report on ABE and CBE editing in a virtually unrestricted sequence context or to label base edited...

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Detalles Bibliográficos
Autores principales: Tálas, András, Simon, Dorottya A., Kulcsár, Péter I., Varga, Éva, Krausz, Sarah L., Welker, Ervin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566456/
https://www.ncbi.nlm.nih.gov/pubmed/34732717
http://dx.doi.org/10.1038/s41467-021-26461-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566456/
https://www.ncbi.nlm.nih.gov/pubmed/34732717
http://dx.doi.org/10.1038/s41467-021-26461-y

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