Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the E3 ubiquiti...

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Detalles Bibliográficos
Autores principales: Mahlokozera, Tatenda, Patel, Bhuvic, Chen, Hao, Desouza, Patrick, Qu, Xuan, Mao, Diane D., Hafez, Daniel, Yang, Wei, Taiwo, Rukayat, Paturu, Mounica, Salehi, Afshin, Gujar, Amit D., Dunn, Gavin P., Mosammaparast, Nima, Petti, Allegra A., Yano, Hiroko, Kim, Albert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566473/
https://www.ncbi.nlm.nih.gov/pubmed/34732716
http://dx.doi.org/10.1038/s41467-021-26653-6

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