Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

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Adjuvants are critical for improving the quality and magnitude of adaptive immune responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanism of act...

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Detalles Bibliográficos
Autores principales: Alameh, Mohamad-Gabriel, Tombácz, István, Bettini, Emily, Lederer, Katlyn, Ndeupen, Sonia, Sittplangkoon, Chutamath, Wilmore, Joel R., Gaudette, Brian T., Soliman, Ousamah Y., Pine, Matthew, Hicks, Philip, Manzoni, Tomaz B., Knox, James J., Johnson, John L., Laczkó, Dorottya, Muramatsu, Hiromi, Davis, Benjamin, Meng, Wenzhao, Rosenfeld, Aaron M., Strohmeier, Shirin, Lin, Paulo J.C., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Jacquet, Alain, Krammer, Florian, Bates, Paul, Cancro, Michael P., Weissman, Drew, Luning Prak, Eline T., Allman, David, Igyártó, Botond Z., Locci, Michela, Pardi, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566475/
https://www.ncbi.nlm.nih.gov/pubmed/34852217
http://dx.doi.org/10.1016/j.immuni.2021.11.001
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