Cargando…

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

Type I Interferon (IFN) was the very first drug approved for the treatment of Multiple Sclerosis (MS), and is still frequently used as a first line therapy. However, systemic IFN also causes considerable side effects, affecting therapy adherence and dose escalation. In addition, the mechanism of act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cauwels, Anje, Van Lint, Sandra, Rogge, Elke, Verhee, Annick, Van Den Eeckhout, Bram, Pang, Shengru, Prinz, Marco, Kley, Niko, Uzé, Gilles, Tavernier, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566508/ https://www.ncbi.nlm.nih.gov/pubmed/34732771 http://dx.doi.org/10.1038/s41598-021-00891-6

Ejemplares similares

A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
por: Van Lint, Sandra, et al.
Publicado: (2023)

Selective IL-1 activity on CD8(+) T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication
por: Van Den Eeckhout, Bram, et al.
Publicado: (2021)

Safe eradication of large established tumors using neovasculature‐targeted tumor necrosis factor‐based therapies
por: Huyghe, Leander, et al.
Publicado: (2020)

Specific targeting of IL-1β activity to CD8(+) T cells allows for safe use as a vaccine adjuvant
por: Van Den Eeckhout, Bram, et al.
Publicado: (2020)

Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock
por: Cauwels, Anje, et al.
Publicado: (2010)

Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides
por: Pfeil, Jennifer, et al.
Publicado: (2021)

Tolerogenic and Activatory Plasmacytoid Dendritic Cells in Autoimmunity
por: Guéry, Leslie, et al.
Publicado: (2013)

Tolerizing Strategies for the Treatment of Autoimmune Diseases: From ex vivo to in vivo Strategies
por: Cauwels, Anje, et al.
Publicado: (2020)

The Soluble Guanylate Cyclase Activator BAY 58-2667 Protects against Morbidity and Mortality in Endotoxic Shock by Recoupling Organ Systems
por: Vandendriessche, Benjamin, et al.
Publicado: (2013)

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems
por: Vandendriessche, Benjamin, et al.
Publicado: (2013)

Hypoxia promotes the tolerogenic phenotype of plasmacytoid dendritic cells in head and neck squamous cell carcinoma
por: Fan, Cui, et al.
Publicado: (2021)

NO-insensitive sGCbeta1 H105F knockin mice: if NO has no place to go
por: Thoonen, Robrecht, et al.
Publicado: (2009)

Tolerogenic Plasmacytoid Dendritic Cells Control Paracoccidioides brasiliensis Infection by Inducting Regulatory T Cells in an IDO-Dependent Manner
por: de Araújo, Eliseu Frank, et al.
Publicado: (2016)

Rethinking EAE pathogenesis
por: Van Epps, Heather L.
Publicado: (2005)

PARing down EAE
por: Van Epps, Heather L.
Publicado: (2006)

Phenotypes of sGC mutant mice in basic conditions, disease and shock
por: Brouckaert, Peter, et al.
Publicado: (2009)

Tolerogenic vaccines for the treatment of cardiovascular diseases
por: Vigario, Fernando Lozano, et al.
Publicado: (2020)

An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE
por: Stoolman, Joshua S., et al.
Publicado: (2018)

Interleukin-1 as Innate Mediator of T Cell Immunity
por: Van Den Eeckhout, Bram, et al.
Publicado: (2021)

An integrin axis induces IFN-β production in plasmacytoid dendritic cells
por: Simoes, Davina Camargo Madeira, et al.
Publicado: (2022)

Thomas Rivers and the EAE model
por: Van Epps, Heather L.
Publicado: (2005)

Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis
por: Lees, Jason R., et al.
Publicado: (2008)

Phenotypical Diversification of Early IFNα-Producing Human Plasmacytoid Dendritic Cells Using Droplet-Based Microfluidics
por: Van Eyndhoven, Laura C., et al.
Publicado: (2021)

MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock
por: Vandendriessche, Benjamin, et al.
Publicado: (2014)

Direct and indirect anti-leukemic properties of activity-on-target interferons for the treatment of T-cell acute lymphoblastic leukemia
por: Goossens, Steven, et al.
Publicado: (2021)

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells
por: Maarifi, Ghizlane, et al.
Publicado: (2019)

Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells
por: Pouw, Juliëtte N, et al.
Publicado: (2022)

Human uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy
por: Feyaerts, Dorien, et al.
Publicado: (2017)

Decreased Neurofilament L Chain Levels in Cerebrospinal Fluid and Tolerogenic Plasmacytoid Dendritic Cells in Natalizumab-Treated Multiple Sclerosis Patients – Brief Research Report
por: Moraes, Adriel S., et al.
Publicado: (2021)

Nitric oxide synthase 2-derived NO in endotoxemia is not sufficient to cause hemodynamic effects
por: Brouckaert, P, et al.
Publicado: (2008)

Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort
por: Grünhagel, Benjamin, et al.
Publicado: (2023)

Tolerogenic therapies in transplantation
por: Page, Eugenia K., et al.
Publicado: (2012)

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
por: Guiducci, Cristiana, et al.
Publicado: (2008)

Hypoxic NO-donor nitrite protects sGC-dependently against morbidity and mortality associated with sterile inflammatory shock in mice
por: Cauwels, A, et al.
Publicado: (2011)

Extracellular ATP drives systemic inflammation, tissue damage and mortality
por: Cauwels, A, et al.
Publicado: (2014)

Targeting Signaling Pathway Downstream of RIG-I/MAVS in the CNS Stimulates Production of Endogenous Type I IFN and Suppresses EAE
por: Kronborg Hansen, Anne K., et al.
Publicado: (2022)

Transplantation of human adipose-derived stem cells overexpressing LIF/IFN-β promotes recovery in experimental autoimmune encephalomyelitis (EAE)
por: Yousefi, Mahdieh, et al.
Publicado: (2022)

Role of Microglia and Macrophages in Eae
por: Raivich, Gennadij, et al.
Publicado: (2005)

HIV Delays IFN-α Production from Human Plasmacytoid Dendritic Cells and Is Associated with SYK Phosphorylation
por: Lo, Calvin C., et al.
Publicado: (2012)

Rhinovirus stimulated IFN-α production: how important are plasmacytoid DCs, monocytes and endosomal pH?
por: Xi, Yang, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7v7fclf5p1ofpa7e96bgfrofl4