Dual function of HPF1 in the modulation of PARP1 and PARP2 activities

Poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerases (PARPs) is one of the immediate cellular responses to DNA damage. The histone PARylation factor 1 (HPF1) discovered recently to form a joint active site with PARP1 and PARP2 was shown to limit the PARylation activity of PARPs and stimu...

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Detalles Bibliográficos
Autores principales: Kurgina, Tatyana A., Moor, Nina A., Kutuzov, Mikhail M., Naumenko, Konstantin N., Ukraintsev, Alexander A., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566583/
https://www.ncbi.nlm.nih.gov/pubmed/34732825
http://dx.doi.org/10.1038/s42003-021-02780-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566583/
https://www.ncbi.nlm.nih.gov/pubmed/34732825
http://dx.doi.org/10.1038/s42003-021-02780-0

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