Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration of normal ribosomal activity. While the role of PPP1R15A has b...

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Detalles Bibliográficos
Autores principales: Monkley, Susan, Overed-Sayer, Catherine, Parfrey, Helen, Rassl, Doris, Crowther, Damian, Escudero-Ibarz, Leire, Davis, Nicola, Carruthers, Alan, Berks, Richard, Coetzee, Marisa, Kolosionek, Ewa, Karlsson, Maria, Griffin, Leia R., Clausen, Maryam, Belfield, Graham, Hogaboam, Cory M., Murray, Lynne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566588/
https://www.ncbi.nlm.nih.gov/pubmed/34732748
http://dx.doi.org/10.1038/s41598-021-00769-7

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