Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use. Herein we perform in vivo shRNA screening to identify targets generally associated with radiation response as well as those exhibiting a genomic dependency....

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Manish, Molkentine, David, Molkentine, Jessica, Bridges, Kathleen, Xie, Tongxin, Yang, Liangpeng, Hefner, Andrew, Gao, Meng, Bahri, Reshub, Dhawan, Annika, Frederick, Mitchell J., Seth, Sahil, Abdelhakiem, Mohamed, Beadle, Beth M., Johnson, Faye, Wang, Jing, Shen, Li, Heffernan, Timothy, Sheth, Aakash, Ferris, Robert L., Myers, Jeffrey N., Pickering, Curtis R., Skinner, Heath D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566594/
https://www.ncbi.nlm.nih.gov/pubmed/34732714
http://dx.doi.org/10.1038/s41467-021-26570-8

Ejemplares similares

Ejemplares similares