Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia

The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade. The first part of this review summarizes the pathogenesis of schizophrenia, especially the negative symptoms an...

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Autores principales: Wu, Qiongqiong, Wang, Xiaoyi, Wang, Ying, Long, Yu-Jun, Zhao, Jing-Ping, Wu, Ren-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566616/
https://www.ncbi.nlm.nih.gov/pubmed/34227057
http://dx.doi.org/10.1007/s12264-021-00740-6
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author Wu, Qiongqiong
Wang, Xiaoyi
Wang, Ying
Long, Yu-Jun
Zhao, Jing-Ping
Wu, Ren-Rong
author_facet Wu, Qiongqiong
Wang, Xiaoyi
Wang, Ying
Long, Yu-Jun
Zhao, Jing-Ping
Wu, Ren-Rong
author_sort Wu, Qiongqiong
collection PubMed
description The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade. The first part of this review summarizes the pathogenesis of schizophrenia, especially the negative symptoms and cognitive dysfunction from the perspectives of genetics and epigenetics. The second part describes the novel medications and several advanced physical therapies (e.g., transcranial magnetic stimulation and transcranial direct current stimulation) for the negative symptoms and cognitive dysfunction that will optimize the therapeutic strategy for patients with schizophrenia in future.
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spelling pubmed-85666162021-11-15 Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia Wu, Qiongqiong Wang, Xiaoyi Wang, Ying Long, Yu-Jun Zhao, Jing-Ping Wu, Ren-Rong Neurosci Bull Review The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade. The first part of this review summarizes the pathogenesis of schizophrenia, especially the negative symptoms and cognitive dysfunction from the perspectives of genetics and epigenetics. The second part describes the novel medications and several advanced physical therapies (e.g., transcranial magnetic stimulation and transcranial direct current stimulation) for the negative symptoms and cognitive dysfunction that will optimize the therapeutic strategy for patients with schizophrenia in future. Springer Singapore 2021-07-05 /pmc/articles/PMC8566616/ /pubmed/34227057 http://dx.doi.org/10.1007/s12264-021-00740-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Wu, Qiongqiong
Wang, Xiaoyi
Wang, Ying
Long, Yu-Jun
Zhao, Jing-Ping
Wu, Ren-Rong
Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia
title Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia
title_full Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia
title_fullStr Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia
title_full_unstemmed Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia
title_short Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia
title_sort developments in biological mechanisms and treatments for negative symptoms and cognitive dysfunction of schizophrenia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566616/
https://www.ncbi.nlm.nih.gov/pubmed/34227057
http://dx.doi.org/10.1007/s12264-021-00740-6
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