The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment

Ongoing research has strongly suggested the role the immune system plays in the pathogenesis of neuropathic pain. T cells appear to be one of the main regulators of the immune system with many mediators appearing to promote or suppress pain resolution. Limited effective therapies are available for t...

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Detalles Bibliográficos
Autores principales: Galvin, DA, C, McCrory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566770/
https://www.ncbi.nlm.nih.gov/pubmed/34761242
http://dx.doi.org/10.1016/j.bbih.2021.100371
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author Galvin, DA
C, McCrory
author_facet Galvin, DA
C, McCrory
author_sort Galvin, DA
collection PubMed
description Ongoing research has strongly suggested the role the immune system plays in the pathogenesis of neuropathic pain. T cells appear to be one of the main regulators of the immune system with many mediators appearing to promote or suppress pain resolution. Limited effective therapies are available for treatment of neuropathic pain. Treatments available appear to modulate specific T cell with altered ratios present 3 months post treatment and parallels clinical improvement. This further supports the neuro-immune basis for neuropathic pain chronicity. Identification of novel immune mediators involved in pain development may suggest new target areas in treatment.
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spelling pubmed-85667702021-11-09 The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment Galvin, DA C, McCrory Brain Behav Immun Health Review Ongoing research has strongly suggested the role the immune system plays in the pathogenesis of neuropathic pain. T cells appear to be one of the main regulators of the immune system with many mediators appearing to promote or suppress pain resolution. Limited effective therapies are available for treatment of neuropathic pain. Treatments available appear to modulate specific T cell with altered ratios present 3 months post treatment and parallels clinical improvement. This further supports the neuro-immune basis for neuropathic pain chronicity. Identification of novel immune mediators involved in pain development may suggest new target areas in treatment. Elsevier 2021-10-20 /pmc/articles/PMC8566770/ /pubmed/34761242 http://dx.doi.org/10.1016/j.bbih.2021.100371 Text en © 2021 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Galvin, DA
C, McCrory
The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment
title The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment
title_full The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment
title_fullStr The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment
title_full_unstemmed The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment
title_short The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment
title_sort role of t-lymphocytes in neuropathic pain initiation, development of chronicity and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566770/
https://www.ncbi.nlm.nih.gov/pubmed/34761242
http://dx.doi.org/10.1016/j.bbih.2021.100371
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