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Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation

The global population is aging, and elderly people have a higher incidence of lower airway diseases owing to decline in swallowing function, airway ciliary motility, and overall immunity associated with aging. Furthermore, lower airway diseases in the elderly tend to have a high mortality rate. Thei...

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Autores principales: Imai, Kenichi, Iinuma, Toshimitsu, Sato, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566873/
https://www.ncbi.nlm.nih.gov/pubmed/34760030
http://dx.doi.org/10.1016/j.jdsr.2021.10.003
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author Imai, Kenichi
Iinuma, Toshimitsu
Sato, Shuichi
author_facet Imai, Kenichi
Iinuma, Toshimitsu
Sato, Shuichi
author_sort Imai, Kenichi
collection PubMed
description The global population is aging, and elderly people have a higher incidence of lower airway diseases owing to decline in swallowing function, airway ciliary motility, and overall immunity associated with aging. Furthermore, lower airway diseases in the elderly tend to have a high mortality rate. Their prevention is important for extending healthy life expectancy and improving the quality of life of each individual. In recent years, the relationship between “chronic periodontitis and oral bacteria, especially the periodontopathic ones” and “respiratory diseases” (e.g., pneumonia, chronic obstructive pulmonary disease, and influenza) has become clear. In addition, the association of several periodontal pathogens with the onset and aggravation of coronavirus disease 2019 (COVID-19) is also being reported. In support of these findings, oral health management has shown to reduce deaths from pneumonia and prevent influenza in nursing homes and inpatient wards. This has led to clinical and multidisciplinary cooperation between physicians and dentists, among others. However, to date, the mechanisms by which “chronic periodontitis and oral bacteria” contribute to lower airway diseases have not been well understood. Clarifying these mechanisms will lead to a theoretical basis for answering the question, “Why is oral health management effective in preventing lower airway diseases?”
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spelling pubmed-85668732021-11-09 Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation Imai, Kenichi Iinuma, Toshimitsu Sato, Shuichi Jpn Dent Sci Rev Review Article The global population is aging, and elderly people have a higher incidence of lower airway diseases owing to decline in swallowing function, airway ciliary motility, and overall immunity associated with aging. Furthermore, lower airway diseases in the elderly tend to have a high mortality rate. Their prevention is important for extending healthy life expectancy and improving the quality of life of each individual. In recent years, the relationship between “chronic periodontitis and oral bacteria, especially the periodontopathic ones” and “respiratory diseases” (e.g., pneumonia, chronic obstructive pulmonary disease, and influenza) has become clear. In addition, the association of several periodontal pathogens with the onset and aggravation of coronavirus disease 2019 (COVID-19) is also being reported. In support of these findings, oral health management has shown to reduce deaths from pneumonia and prevent influenza in nursing homes and inpatient wards. This has led to clinical and multidisciplinary cooperation between physicians and dentists, among others. However, to date, the mechanisms by which “chronic periodontitis and oral bacteria” contribute to lower airway diseases have not been well understood. Clarifying these mechanisms will lead to a theoretical basis for answering the question, “Why is oral health management effective in preventing lower airway diseases?” Elsevier 2021-11 2021-10-28 /pmc/articles/PMC8566873/ /pubmed/34760030 http://dx.doi.org/10.1016/j.jdsr.2021.10.003 Text en © 2021 Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Imai, Kenichi
Iinuma, Toshimitsu
Sato, Shuichi
Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation
title Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation
title_full Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation
title_fullStr Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation
title_full_unstemmed Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation
title_short Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation
title_sort relationship between the oral cavity and respiratory diseases: aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566873/
https://www.ncbi.nlm.nih.gov/pubmed/34760030
http://dx.doi.org/10.1016/j.jdsr.2021.10.003
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