The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview

Live attenuated Bacillus Calmette-Guérin (BCG) is the world’s most widely used vaccine which is mainly administered for its protection against tuberculosis (TB), particularly in young children. However, since its initial use over 100years ago, it has also proven to offer a level of protection agains...

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Autores principales: Mouhoub, Esma, Domenech, Pilar, Ndao, Momar, Reed, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566895/
https://www.ncbi.nlm.nih.gov/pubmed/34745066
http://dx.doi.org/10.3389/fmicb.2021.757858
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author Mouhoub, Esma
Domenech, Pilar
Ndao, Momar
Reed, Michael B.
author_facet Mouhoub, Esma
Domenech, Pilar
Ndao, Momar
Reed, Michael B.
author_sort Mouhoub, Esma
collection PubMed
description Live attenuated Bacillus Calmette-Guérin (BCG) is the world’s most widely used vaccine which is mainly administered for its protection against tuberculosis (TB), particularly in young children. However, since its initial use over 100years ago, it has also proven to offer a level of protection against various other pathogens, as a consequence of its non-specific immune enhancing effects. Thus, over the past few decades, recombinant BCG (rBCG) technology has been used as a vector to create rBCG vaccines expressing heterologous antigens that elicit immunity against a range of bacterial, viral, and parasitic diseases. Our goal with this mini-review is to provide an up-to-date survey of the various techniques, approaches, and applications of rBCG-based vaccines for targeting infectious diseases other than TB.
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spelling pubmed-85668952021-11-05 The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview Mouhoub, Esma Domenech, Pilar Ndao, Momar Reed, Michael B. Front Microbiol Microbiology Live attenuated Bacillus Calmette-Guérin (BCG) is the world’s most widely used vaccine which is mainly administered for its protection against tuberculosis (TB), particularly in young children. However, since its initial use over 100years ago, it has also proven to offer a level of protection against various other pathogens, as a consequence of its non-specific immune enhancing effects. Thus, over the past few decades, recombinant BCG (rBCG) technology has been used as a vector to create rBCG vaccines expressing heterologous antigens that elicit immunity against a range of bacterial, viral, and parasitic diseases. Our goal with this mini-review is to provide an up-to-date survey of the various techniques, approaches, and applications of rBCG-based vaccines for targeting infectious diseases other than TB. Frontiers Media S.A. 2021-10-21 /pmc/articles/PMC8566895/ /pubmed/34745066 http://dx.doi.org/10.3389/fmicb.2021.757858 Text en Copyright © 2021 Mouhoub, Domenech, Ndao and Reed. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Mouhoub, Esma
Domenech, Pilar
Ndao, Momar
Reed, Michael B.
The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview
title The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview
title_full The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview
title_fullStr The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview
title_full_unstemmed The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview
title_short The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview
title_sort diverse applications of recombinant bcg-based vaccines to target infectious diseases other than tuberculosis: an overview
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566895/
https://www.ncbi.nlm.nih.gov/pubmed/34745066
http://dx.doi.org/10.3389/fmicb.2021.757858
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