Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome

Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with...

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Autores principales: Chebly, Alain, Djambas Khayat, Claudia, Yammine, Tony, Korban, Rima, Semaan, Warde, Bou Zeid, Jessica, Farra, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566899/
https://www.ncbi.nlm.nih.gov/pubmed/34760618
http://dx.doi.org/10.1016/j.lrr.2021.100277
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author Chebly, Alain
Djambas Khayat, Claudia
Yammine, Tony
Korban, Rima
Semaan, Warde
Bou Zeid, Jessica
Farra, Chantal
author_facet Chebly, Alain
Djambas Khayat, Claudia
Yammine, Tony
Korban, Rima
Semaan, Warde
Bou Zeid, Jessica
Farra, Chantal
author_sort Chebly, Alain
collection PubMed
description Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6. The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML-MLL-SEPT6 cases.
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spelling pubmed-85668992021-11-09 Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome Chebly, Alain Djambas Khayat, Claudia Yammine, Tony Korban, Rima Semaan, Warde Bou Zeid, Jessica Farra, Chantal Leuk Res Rep Article Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6. The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML-MLL-SEPT6 cases. Elsevier 2021-10-26 /pmc/articles/PMC8566899/ /pubmed/34760618 http://dx.doi.org/10.1016/j.lrr.2021.100277 Text en © 2021 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chebly, Alain
Djambas Khayat, Claudia
Yammine, Tony
Korban, Rima
Semaan, Warde
Bou Zeid, Jessica
Farra, Chantal
Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome
title Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome
title_full Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome
title_fullStr Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome
title_full_unstemmed Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome
title_short Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome
title_sort pediatric m5 acute myeloid leukemia with mll-sept6 fusion and a favorable outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566899/
https://www.ncbi.nlm.nih.gov/pubmed/34760618
http://dx.doi.org/10.1016/j.lrr.2021.100277
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