A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice

Dysregulation of CXCL12/SDF-1-CXCR4/CD184 signaling is associated with inflammatory diseases and notably with systemic lupus erythematosus. Issued from the lead molecule chalcone-4, the first neutraligand of the CXCL12 chemokine, LIT-927 was recently described as a potent analogue with improved solu...

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Detalles Bibliográficos
Autores principales: Schall, Nicolas, Daubeuf, François, Marsol, Claire, Gizzi, Patrick, Frossard, Nelly, Bonnet, Dominique, Galzi, Jean-Luc, Muller, Sylviane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566942/
https://www.ncbi.nlm.nih.gov/pubmed/34744730
http://dx.doi.org/10.3389/fphar.2021.752194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566942/
https://www.ncbi.nlm.nih.gov/pubmed/34744730
http://dx.doi.org/10.3389/fphar.2021.752194

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