Phagocytic microglia in development: Are they what they eat?

Microglia, the innate immune cells of the brain, are indispensable for proper brain development. As professional phagocytes, microglia engulf other cells within distinct developmental niches to sculpt the architecture of the brain. Here, I highlight the age-, brain region-, and substrate-dependent d...

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Detalles Bibliográficos
Autor principal: VanRyzin, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Articles from the Special Issue on Emerging PNI research: future leaders in focus; Edited by Amanda Kentner, Lois Harden, Denis de Melo Soares and Christoph Rummel
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566956/
https://www.ncbi.nlm.nih.gov/pubmed/34761244
http://dx.doi.org/10.1016/j.bbih.2021.100373
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author VanRyzin, Jonathan W.
author_facet VanRyzin, Jonathan W.
author_sort VanRyzin, Jonathan W.
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description Microglia, the innate immune cells of the brain, are indispensable for proper brain development. As professional phagocytes, microglia engulf other cells within distinct developmental niches to sculpt the architecture of the brain. Here, I highlight the age-, brain region-, and substrate-dependent diversity of developmental phagocytosis, and pose the idea that phagocytosis may, in turn, drive changes in microglia phenotype. Ultimately, phagocytosis might be just as important for shaping microglia function as it is for shaping the brain.
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spelling pubmed-85669562021-11-09 Phagocytic microglia in development: Are they what they eat? VanRyzin, Jonathan W. Brain Behav Immun Health Articles from the Special Issue on Emerging PNI research: future leaders in focus; Edited by Amanda Kentner, Lois Harden, Denis de Melo Soares and Christoph Rummel Microglia, the innate immune cells of the brain, are indispensable for proper brain development. As professional phagocytes, microglia engulf other cells within distinct developmental niches to sculpt the architecture of the brain. Here, I highlight the age-, brain region-, and substrate-dependent diversity of developmental phagocytosis, and pose the idea that phagocytosis may, in turn, drive changes in microglia phenotype. Ultimately, phagocytosis might be just as important for shaping microglia function as it is for shaping the brain. Elsevier 2021-10-20 /pmc/articles/PMC8566956/ /pubmed/34761244 http://dx.doi.org/10.1016/j.bbih.2021.100373 Text en © 2021 The Author https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Articles from the Special Issue on Emerging PNI research: future leaders in focus; Edited by Amanda Kentner, Lois Harden, Denis de Melo Soares and Christoph Rummel
VanRyzin, Jonathan W.
Phagocytic microglia in development: Are they what they eat?
title Phagocytic microglia in development: Are they what they eat?
title_full Phagocytic microglia in development: Are they what they eat?
title_fullStr Phagocytic microglia in development: Are they what they eat?
title_full_unstemmed Phagocytic microglia in development: Are they what they eat?
title_short Phagocytic microglia in development: Are they what they eat?
title_sort phagocytic microglia in development: are they what they eat?
topic Articles from the Special Issue on Emerging PNI research: future leaders in focus; Edited by Amanda Kentner, Lois Harden, Denis de Melo Soares and Christoph Rummel
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566956/
https://www.ncbi.nlm.nih.gov/pubmed/34761244
http://dx.doi.org/10.1016/j.bbih.2021.100373
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