Cargando…

The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond

Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been studied in multiple contexts and grown into a multifunctional protein. In addition to the extensive functional study of Ku70 in DNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Sui, Hongyan, Hao, Ming, Chang, Weizhong, Imamichi, Tomozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566972/
https://www.ncbi.nlm.nih.gov/pubmed/34746031
http://dx.doi.org/10.3389/fcimb.2021.761983
_version_ 1784594133230288896
author Sui, Hongyan
Hao, Ming
Chang, Weizhong
Imamichi, Tomozumi
author_facet Sui, Hongyan
Hao, Ming
Chang, Weizhong
Imamichi, Tomozumi
author_sort Sui, Hongyan
collection PubMed
description Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been studied in multiple contexts and grown into a multifunctional protein. In addition to the extensive functional study of Ku70 in DNA repair process, many studies have emphasized the role of Ku70 in various other cellular processes, including apoptosis, aging, and HIV replication. In this review, we focus on discussing the role of Ku70 in inducing interferons and proinflammatory cytokines as a cytosolic DNA sensor. We explored the unique structure of Ku70 binding with DNA; illustrated, with evidence, how Ku70, as a nuclear protein, responds to extracellular DNA stimulation; and summarized the mechanisms of the Ku70-involved innate immune response pathway. Finally, we discussed several new strategies to modulate Ku70-mediated innate immune response and highlighted some potential physiological insights based on the role of Ku70 in innate immunity.
format Online
Article
Text
id pubmed-8566972
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85669722021-11-05 The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond Sui, Hongyan Hao, Ming Chang, Weizhong Imamichi, Tomozumi Front Cell Infect Microbiol Cellular and Infection Microbiology Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been studied in multiple contexts and grown into a multifunctional protein. In addition to the extensive functional study of Ku70 in DNA repair process, many studies have emphasized the role of Ku70 in various other cellular processes, including apoptosis, aging, and HIV replication. In this review, we focus on discussing the role of Ku70 in inducing interferons and proinflammatory cytokines as a cytosolic DNA sensor. We explored the unique structure of Ku70 binding with DNA; illustrated, with evidence, how Ku70, as a nuclear protein, responds to extracellular DNA stimulation; and summarized the mechanisms of the Ku70-involved innate immune response pathway. Finally, we discussed several new strategies to modulate Ku70-mediated innate immune response and highlighted some potential physiological insights based on the role of Ku70 in innate immunity. Frontiers Media S.A. 2021-10-21 /pmc/articles/PMC8566972/ /pubmed/34746031 http://dx.doi.org/10.3389/fcimb.2021.761983 Text en Copyright © 2021 Sui, Hao, Chang and Imamichi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Sui, Hongyan
Hao, Ming
Chang, Weizhong
Imamichi, Tomozumi
The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond
title The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond
title_full The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond
title_fullStr The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond
title_full_unstemmed The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond
title_short The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond
title_sort role of ku70 as a cytosolic dna sensor in innate immunity and beyond
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566972/
https://www.ncbi.nlm.nih.gov/pubmed/34746031
http://dx.doi.org/10.3389/fcimb.2021.761983
work_keys_str_mv AT suihongyan theroleofku70asacytosolicdnasensorininnateimmunityandbeyond
AT haoming theroleofku70asacytosolicdnasensorininnateimmunityandbeyond
AT changweizhong theroleofku70asacytosolicdnasensorininnateimmunityandbeyond
AT imamichitomozumi theroleofku70asacytosolicdnasensorininnateimmunityandbeyond
AT suihongyan roleofku70asacytosolicdnasensorininnateimmunityandbeyond
AT haoming roleofku70asacytosolicdnasensorininnateimmunityandbeyond
AT changweizhong roleofku70asacytosolicdnasensorininnateimmunityandbeyond
AT imamichitomozumi roleofku70asacytosolicdnasensorininnateimmunityandbeyond