A new gene on C. elegans chromosome V

C. elegans was the first animal to have its genome completely sequenced. In the decades since, the genome continues to be actively curated, annotated, and improved. Here we report the discovery of a new gene in a region of the genome that is currently not associated with any annotated gene or featur...

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Detalles Bibliográficos
Autores principales: Iyengar, Anusha, Diamantakis, Stavros, Norris, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567090/
https://www.ncbi.nlm.nih.gov/pubmed/34746681
http://dx.doi.org/10.17912/micropub.biology.000496
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author Iyengar, Anusha
Diamantakis, Stavros
Norris, Adam
author_facet Iyengar, Anusha
Diamantakis, Stavros
Norris, Adam
author_sort Iyengar, Anusha
collection PubMed
description C. elegans was the first animal to have its genome completely sequenced. In the decades since, the genome continues to be actively curated, annotated, and improved. Here we report the discovery of a new gene in a region of the genome that is currently not associated with any annotated gene or feature. We present RNA-seq and RT-PCR evidence that this gene is expressed at detectable levels, and that it is alternatively spliced. The new gene (Y97E10C.2) shares an operon with two upstream genes. We provide RNA-seq and RT-PCR evidence for a missing exon in the upstream gene T05B11.7, as well as an alternatively-spliced exon.
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spelling pubmed-85670902021-11-05 A new gene on C. elegans chromosome V Iyengar, Anusha Diamantakis, Stavros Norris, Adam MicroPubl Biol New Finding C. elegans was the first animal to have its genome completely sequenced. In the decades since, the genome continues to be actively curated, annotated, and improved. Here we report the discovery of a new gene in a region of the genome that is currently not associated with any annotated gene or feature. We present RNA-seq and RT-PCR evidence that this gene is expressed at detectable levels, and that it is alternatively spliced. The new gene (Y97E10C.2) shares an operon with two upstream genes. We provide RNA-seq and RT-PCR evidence for a missing exon in the upstream gene T05B11.7, as well as an alternatively-spliced exon. Caltech Library 2021-11-03 /pmc/articles/PMC8567090/ /pubmed/34746681 http://dx.doi.org/10.17912/micropub.biology.000496 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Iyengar, Anusha
Diamantakis, Stavros
Norris, Adam
A new gene on C. elegans chromosome V
title A new gene on C. elegans chromosome V
title_full A new gene on C. elegans chromosome V
title_fullStr A new gene on C. elegans chromosome V
title_full_unstemmed A new gene on C. elegans chromosome V
title_short A new gene on C. elegans chromosome V
title_sort new gene on c. elegans chromosome v
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567090/
https://www.ncbi.nlm.nih.gov/pubmed/34746681
http://dx.doi.org/10.17912/micropub.biology.000496
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