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Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations
BACKGROUND: Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients immediately after thawing the cryopreserved product (out-of-thaw), yet little is known about the single-cell transcriptomic landsc...
Autores principales: | Medrano-Trochez, Camila, Chatterjee, Paramita, Pradhan, Pallab, Stevens, Hazel Y., Ogle, Molly E., Botchwey, Edward A., Kurtzberg, Joanne, Yeago, Carolyn, Gibson, Greg, Roy, Krishnendu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567133/ https://www.ncbi.nlm.nih.gov/pubmed/34736534 http://dx.doi.org/10.1186/s13287-021-02627-9 |
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