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Hepsin regulates TGFβ signaling via fibronectin proteolysis
Transforming growth factor‐beta (TGFβ) is a multifunctional cytokine with a well‐established role in mammary gland development and both oncogenic and tumor‐suppressive functions. The extracellular matrix (ECM) indirectly regulates TGFβ activity by acting as a storage compartment of latent‐TGFβ, but...
Autores principales: | Belitškin, Denis, Pant, Shishir M, Munne, Pauliina, Suleymanova, Ilida, Belitškina, Kati, Hongisto, Hanna‐Ala, Englund, Johanna, Raatikainen, Tiina, Klezovitch, Olga, Vasioukhin, Valeri, Li, Shuo, Wu, Qingyu, Monni, Outi, Kuure, Satu, Laakkonen, Pirjo, Pouwels, Jeroen, Tervonen, Topi A, Klefström, Juha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567232/ https://www.ncbi.nlm.nih.gov/pubmed/34515392 http://dx.doi.org/10.15252/embr.202152532 |
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