Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses

The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM is a negative regulator of IFN responses under basal conditions. However, the role of human IRGM during viral infection has remained unclear. In this study, we show that IRGM expression is increased upon vi...

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Detalles Bibliográficos
Autores principales: Nath, Parej, Chauhan, Nishant Ranjan, Jena, Kautilya Kumar, Datey, Ankita, Kumar, Nilima Dinesh, Mehto, Subhash, De, Saikat, Nayak, Tapas Kumar, Priyadarsini, Swatismita, Rout, Kshitish, Bal, Ramyasingh, Murmu, Krushna C, Kalia, Manjula, Patnaik, Srinivas, Prasad, Punit, Reggiori, Fulvio, Chattopadhyay, Soma, Chauhan, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567234/
https://www.ncbi.nlm.nih.gov/pubmed/34467632
http://dx.doi.org/10.15252/embr.202152948

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