A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles

The production of (18)F-labelled microbubbles (MBs) via the aluminium-[(18)F]fluoride ([(18)F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [(18)F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>9...

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Detalles Bibliográficos
Autores principales: Teh, Jin Hui, Braga, Marta, Allott, Louis, Barnes, Chris, Hernández-Gil, Javier, Tang, Meng-Xing, Aboagye, Eric O., Long, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567295/
https://www.ncbi.nlm.nih.gov/pubmed/34672307
http://dx.doi.org/10.1039/d1cc04790f
Descripción
Sumario:The production of (18)F-labelled microbubbles (MBs) via the aluminium-[(18)F]fluoride ([(18)F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [(18)F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40–50% RCY), which was incorporated into MBs (40–50% RCY). To demonstrate the potential of producing (18)F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.

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