A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles

The production of (18)F-labelled microbubbles (MBs) via the aluminium-[(18)F]fluoride ([(18)F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [(18)F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>9...

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Autores principales: Teh, Jin Hui, Braga, Marta, Allott, Louis, Barnes, Chris, Hernández-Gil, Javier, Tang, Meng-Xing, Aboagye, Eric O., Long, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567295/
https://www.ncbi.nlm.nih.gov/pubmed/34672307
http://dx.doi.org/10.1039/d1cc04790f
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author Teh, Jin Hui
Braga, Marta
Allott, Louis
Barnes, Chris
Hernández-Gil, Javier
Tang, Meng-Xing
Aboagye, Eric O.
Long, Nicholas J.
author_facet Teh, Jin Hui
Braga, Marta
Allott, Louis
Barnes, Chris
Hernández-Gil, Javier
Tang, Meng-Xing
Aboagye, Eric O.
Long, Nicholas J.
author_sort Teh, Jin Hui
collection PubMed
description The production of (18)F-labelled microbubbles (MBs) via the aluminium-[(18)F]fluoride ([(18)F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [(18)F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40–50% RCY), which was incorporated into MBs (40–50% RCY). To demonstrate the potential of producing (18)F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.
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spelling pubmed-85672952021-11-09 A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles Teh, Jin Hui Braga, Marta Allott, Louis Barnes, Chris Hernández-Gil, Javier Tang, Meng-Xing Aboagye, Eric O. Long, Nicholas J. Chem Commun (Camb) Chemistry The production of (18)F-labelled microbubbles (MBs) via the aluminium-[(18)F]fluoride ([(18)F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [(18)F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40–50% RCY), which was incorporated into MBs (40–50% RCY). To demonstrate the potential of producing (18)F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting. The Royal Society of Chemistry 2021-10-15 /pmc/articles/PMC8567295/ /pubmed/34672307 http://dx.doi.org/10.1039/d1cc04790f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Teh, Jin Hui
Braga, Marta
Allott, Louis
Barnes, Chris
Hernández-Gil, Javier
Tang, Meng-Xing
Aboagye, Eric O.
Long, Nicholas J.
A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles
title A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles
title_full A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles
title_fullStr A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles
title_full_unstemmed A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles
title_short A kit-based aluminium-[(18)F]fluoride approach to radiolabelled microbubbles
title_sort kit-based aluminium-[(18)f]fluoride approach to radiolabelled microbubbles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567295/
https://www.ncbi.nlm.nih.gov/pubmed/34672307
http://dx.doi.org/10.1039/d1cc04790f
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