Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies

[Image: see text] A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The...

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Autores principales: Kong, Jia Wen, Lam, Zhiyong, Chan, Kiat Hwa, Ganguly, Rakesh, Joey Lee, Jia-Ying, Loo, Lit-Hsin, Webster, Richard D., Wong, Zhen Xuan, Leong, Weng Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567370/
https://www.ncbi.nlm.nih.gov/pubmed/34746593
http://dx.doi.org/10.1021/acsomega.1c04116
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author Kong, Jia Wen
Lam, Zhiyong
Chan, Kiat Hwa
Ganguly, Rakesh
Joey Lee, Jia-Ying
Loo, Lit-Hsin
Webster, Richard D.
Wong, Zhen Xuan
Leong, Weng Kee
author_facet Kong, Jia Wen
Lam, Zhiyong
Chan, Kiat Hwa
Ganguly, Rakesh
Joey Lee, Jia-Ying
Loo, Lit-Hsin
Webster, Richard D.
Wong, Zhen Xuan
Leong, Weng Kee
author_sort Kong, Jia Wen
collection PubMed
description [Image: see text] A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os(3)(CO)(10)(μ-H)[μ-SC(6)H(4)-p-B(OH)(2)]} (2) could be chemically oxidized to its hydroxy analogue [Os(3)(CO)(10)(μ-H)(μ-SC(6)H(4)-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.
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spelling pubmed-85673702021-11-05 Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies Kong, Jia Wen Lam, Zhiyong Chan, Kiat Hwa Ganguly, Rakesh Joey Lee, Jia-Ying Loo, Lit-Hsin Webster, Richard D. Wong, Zhen Xuan Leong, Weng Kee ACS Omega [Image: see text] A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os(3)(CO)(10)(μ-H)[μ-SC(6)H(4)-p-B(OH)(2)]} (2) could be chemically oxidized to its hydroxy analogue [Os(3)(CO)(10)(μ-H)(μ-SC(6)H(4)-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death. American Chemical Society 2021-10-22 /pmc/articles/PMC8567370/ /pubmed/34746593 http://dx.doi.org/10.1021/acsomega.1c04116 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Kong, Jia Wen
Lam, Zhiyong
Chan, Kiat Hwa
Ganguly, Rakesh
Joey Lee, Jia-Ying
Loo, Lit-Hsin
Webster, Richard D.
Wong, Zhen Xuan
Leong, Weng Kee
Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
title Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
title_full Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
title_fullStr Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
title_full_unstemmed Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
title_short Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
title_sort group viii metal carbonyl cluster-boronic acid conjugates: cytotoxicity and mode of action studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567370/
https://www.ncbi.nlm.nih.gov/pubmed/34746593
http://dx.doi.org/10.1021/acsomega.1c04116
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