Cargando…

AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells

Neutrophil elastase (NE) promotes multiple stages of tumorigenesis. However, little is known regarding the molecular mechanisms underlying its stimulatory role. This study shows that NE triggers dose-dependent ERK signaling and cell migration in a panel of prostate cell lines representing the spectr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Zhiguang, Hammes, Stephen R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567381/ https://www.ncbi.nlm.nih.gov/pubmed/34761189 http://dx.doi.org/10.1016/j.isci.2021.103270

Ejemplares similares

SAT-138 Neutrophil Elastase Promotes Proliferative Signals in Prostate Cells Through EGFR and DDR1
por: Xiao, Zhiguang, et al.
Publicado: (2020)

Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase
por: Bhagat, Anchit, et al.
Publicado: (2022)

OR34-5 Infiltrating Neutrophils and Neutrophil Elastase (NE) Promote Tumor Growth in a Mouse Model for Lymphangioleiomyomatosis (LAM)
por: Taya, Manisha, et al.
Publicado: (2019)

Neutrophil elastase in bronchiectasis
por: Gramegna, Andrea, et al.
Publicado: (2017)

Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia
por: Isono, Toshihito, et al.
Publicado: (2023)

Leukotriene B(4)-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo
por: Colom, Bartomeu, et al.
Publicado: (2015)

The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia
por: Domon, Hisanori, et al.
Publicado: (2021)

Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase
por: Gong, Lei, et al.
Publicado: (2013)

PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema
por: Hou, Hsin-Han, et al.
Publicado: (2014)

YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC
por: Ghiso, Elena, et al.
Publicado: (2017)

The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension
por: Taylor, Shalina, et al.
Publicado: (2018)

Neutrophil Elastase and Chronic Lung Disease
por: Voynow, Judith A., et al.
Publicado: (2021)

Neutrophil Elastase Defects in Congenital Neutropenia
por: Rydzynska, Zuzanna, et al.
Publicado: (2021)

Flavonoids as inhibitors of human neutrophil elastase
por: Jakimiuk, Katarzyna, et al.
Publicado: (2021)

Neutrophil elastase and its therapeutic effect on leukemia cells
por: JIANG, KAI-LING, et al.
Publicado: (2015)

Elastase inhibitor. Characterization of the human elastase inhibitor molecule associated with monocytes, macrophages, and neutrophils
Publicado: (1989)

Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis
por: Wu, Siyu, et al.
Publicado: (2019)

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
por: Papayannopoulos, Venizelos, et al.
Publicado: (2010)

AUY922 Effectively Overcomes MET- and AXL-Mediated Resistance to EGFR-TKI in Lung Cancer Cells
por: Choi, Yun Jung, et al.
Publicado: (2015)

Silver Nanoparticles Induce Neutrophil Extracellular Traps Via Activation of PAD and Neutrophil Elastase
por: Kang, HanGoo, et al.
Publicado: (2021)

Inhibition of Human Neutrophil Elastase by Pentacyclic Triterpenes
por: Feng, Li, et al.
Publicado: (2013)

Neutrophil Elastase Inhibitors and Chronic Kidney Disease
por: Bronze-da-Rocha, Elsa, et al.
Publicado: (2018)

Diazaborines as New Inhibitors of Human Neutrophil Elastase
por: António, João P. M., et al.
Publicado: (2018)

The role of neutrophil elastase in aortic valve calcification
por: Liu, Yan, et al.
Publicado: (2022)

Neutrophil elastase: From mechanisms to therapeutic potential
por: Zeng, Weilin, et al.
Publicado: (2023)

Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer
por: Yan, Dan, et al.
Publicado: (2021)

Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth
por: Houghton, A. McGarry, et al.
Publicado: (2010)

EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating α1-AT
por: Xiaokaiti, Yilixiati, et al.
Publicado: (2015)

Pterostilbene supresses inflammation-induced melanoma metastasis by impeding neutrophil elastase-mediated thrombospondin-1 degradation
por: Su, Dan, et al.
Publicado: (2022)

AXL/epidermal growth factor receptor (EGFR) complexes in breast cancer - culprits for resistance to EGFR inhibitors?
por: Heideman, Marinus R, et al.
Publicado: (2013)

Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis
por: Wen, Guanmei, et al.
Publicado: (2018)

Complex of human neutrophil elastase with 1/2SLPI
por: Koizumi, Masahiro, et al.
Publicado: (2008)

Neutrophil elastase as a biomarker for bacterial infection in COPD
por: Thulborn, Samantha J., et al.
Publicado: (2019)

Neutrophil elastase and endogenous inhibitors in Behçet’s disease saliva
por: Novak, T., et al.
Publicado: (2020)

Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase
por: Leahy, Darren, et al.
Publicado: (2021)

Identification and characterization of aptameric inhibitors of human neutrophil elastase
por: Malicki, Stanisław, et al.
Publicado: (2023)

Activation of the AXL Kinase Causes Resistance to EGFR-Targeted Therapy in Lung Cancer
por: Zhang, Zhenfeng, et al.
Publicado: (2012)

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers
por: Ho, Ai-Sheng, et al.
Publicado: (2014)

Value of circulating neutrophil elastase for detecting recurrence of differentiated thyroid cancer
por: Lee, Hyunjae, et al.
Publicado: (2023)

Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice
por: Yang, Mei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jvv6chr7nq5hj0a13kjum1vuj7