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Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation
Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) driven by viruses or bacteria, as well as in numerous immune-mediated disorders. Histone citrullination by the enzyme peptidylarginine deiminase 4 (PAD4) and the consequent de...
Autores principales: | Poli, Valentina, Pui-Yan Ma, Victor, Di Gioia, Marco, Broggi, Achille, Benamar, Mehdi, Chen, Qian, Mazitschek, Ralph, Haggarty, Stephen J., Chatila, Talal A., Karp, Jeffrey M., Zanoni, Ivan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567386/ https://www.ncbi.nlm.nih.gov/pubmed/34761180 http://dx.doi.org/10.1016/j.isci.2021.103256 |
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