Cargando…

Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease

BACKGROUND: The interaction between the brain and periphery might play a crucial role in the development of Alzheimer’s disease (AD). METHODS: Using blood transcriptomic profile data from two independent AD cohorts, we performed expression quantitative trait locus (cis-eQTL) analysis of 29 significa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Young Ho, Pyun, Jung-Min, Hodges, Angela, Jang, Jae-Won, Bice, Paula J., Kim, SangYun, Saykin, Andrew J., Nho, Kwangsik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567578/ https://www.ncbi.nlm.nih.gov/pubmed/34732252 http://dx.doi.org/10.1186/s13195-021-00919-z

Ejemplares similares

Immunity gene IFITM3 variant: Relation to cognition and Alzheimer's disease pathology
por: Pyun, Jung‐Min, et al.
Publicado: (2022)

miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease
por: Han, Sang-Won, et al.
Publicado: (2023)

BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
por: Kim, Jun Pyo, et al.
Publicado: (2021)

Correction to: BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
por: Kim, Jun Pyo, et al.
Publicado: (2022)

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease
por: Park, Young Ho, et al.
Publicado: (2020)

Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment
por: Pyun, Jung-Min, et al.
Publicado: (2021)

Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer’s disease
por: Lee, Younghee, et al.
Publicado: (2018)

Deep Learning in Alzheimer's Disease: Diagnostic Classification and Prognostic Prediction Using Neuroimaging Data
por: Jo, Taeho, et al.
Publicado: (2019)

Association of peripheral blood DNA methylation level with Alzheimer’s disease progression
por: Li, Qingqin S., et al.
Publicado: (2021)

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data
por: Jo, Taeho, et al.
Publicado: (2023)

Deep learning detection of informative features in tau PET for Alzheimer’s disease classification
por: Jo, Taeho, et al.
Publicado: (2020)

Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression
por: Nho, Kwangsik, et al.
Publicado: (2021)

Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics
por: Hirschfeld, Lauren Rose, et al.
Publicado: (2022)

Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso
por: Xie, Linhui, et al.
Publicado: (2020)

Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment
por: Pyun, Jung-Min, et al.
Publicado: (2017)

Integration of amyloid-β oligomerization tendency as a plasma biomarker in Alzheimer's disease diagnosis
por: Pyun, Jung-Min, et al.
Publicado: (2023)

Circulating lipid profiles are associated with cross-sectional and longitudinal changes of central biomarkers for Alzheimer’s disease
por: Kim, Jun Pyo, et al.
Publicado: (2023)

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study
por: Ramanan, Vijay K., et al.
Publicado: (2013)

Genome-Wide Association Analysis across Endophenotypes in Alzheimer’s Disease: Main Effects and Disease Stage-Specific Interactions
por: Rosewood, Thea J., et al.
Publicado: (2023)

Association of the top 20 Alzheimer's disease risk genes with [(18)F]flortaucipir PET
por: Stage, Eddie, et al.
Publicado: (2022)

GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
por: Todd, Nicholas K., et al.
Publicado: (2022)

Identification of exon skipping events associated with Alzheimer’s disease in the human hippocampus
por: Han, Seonggyun, et al.
Publicado: (2019)

Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains
por: Varathan, Pradeep, et al.
Publicado: (2022)

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease
por: Horgusluoglu-Moloch, Emrin, et al.
Publicado: (2020)

The Relation Between Brain Amyloid Deposition, Cortical Atrophy, and Plasma Biomarkers in Amnesic Mild Cognitive Impairment and Alzheimer’s Disease
por: Fan, Ling-Yun, et al.
Publicado: (2018)

Plasma amyloid beta levels are associated with cerebral amyloid and tau deposition
por: Risacher, Shannon L., et al.
Publicado: (2019)

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease
por: Yan, Jingwen, et al.
Publicado: (2015)

Differential co-expression analysis reveals early stage transcriptomic decoupling in alzheimer’s disease
por: Upadhyaya, Yurika, et al.
Publicado: (2020)

Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging
por: Yan, Qi, et al.
Publicado: (2018)

Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology
por: Barupal, Dinesh Kumar, et al.
Publicado: (2019)

Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer’s disease
por: Kim, Dokyoon, et al.
Publicado: (2017)

From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer's disease relevant SNPs
por: Wang, Hua, et al.
Publicado: (2012)

White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum
por: Hirschfeld, Lauren Rose, et al.
Publicado: (2023)

Alternative Splicing Regulation of an Alzheimer’s Risk Variant in CLU
por: Han, Seonggyun, et al.
Publicado: (2020)

Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study
por: Padilla, Concepcion, et al.
Publicado: (2022)

PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
por: Tsai, Andy P., et al.
Publicado: (2022)

Rare variants in the splicing regulatory elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer’s disease
por: Miller, Jason E., et al.
Publicado: (2018)

Anti-Amyloid Therapy, AD, and ARIA: Untangling the Role of CAA
por: Sin, Mo-Kyung, et al.
Publicado: (2023)

Structural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites
por: Darvill, Nick, et al.
Publicado: (2018)

Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease
por: Youn, Young Chul, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_r4bqnvglrji1lnltfk7apsj0hf