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MSA: reproducible mutational signature attribution with confidence based on simulations
BACKGROUND: Mutational signatures proved to be a useful tool for identifying patterns of mutations in genomes, often providing valuable insights about mutagenic processes or normal DNA damage. De novo extraction of signatures is commonly performed using Non-Negative Matrix Factorisation methods, how...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567580/ https://www.ncbi.nlm.nih.gov/pubmed/34736398 http://dx.doi.org/10.1186/s12859-021-04450-8 |