A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18–SSX Induces Canonical BAF Destruction

Reduced protein levels of SMARCB1 (also known as BAF47, INI1, SNF5) have long been observed in synovial sarcoma. Here, we show that combined Smarcb1 genetic loss with SS18–SSX expression in mice synergized to produce aggressive tumors with histomorphology, transcriptomes, and genome-wide BAF-family...

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Detalles Bibliográficos
Autores principales: Li, Jinxiu, Mulvihill, Timothy S., Li, Li, Barrott, Jared J., Nelson, Mary L., Wagner, Lena, Lock, Ian C., Pozner, Amir, Lambert, Sydney Lynn, Ozenberger, Benjamin B., Ward, Michael B., Grossmann, Allie H., Liu, Ting, Banito, Ana, Cairns, Bradley R., Jones, Kevin B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567602/
https://www.ncbi.nlm.nih.gov/pubmed/34078620
http://dx.doi.org/10.1158/2159-8290.CD-20-1219

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