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Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature

BACKGROUND: Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of variants located in the cytotoxic T lymphocyte-associated protein-4 (CTLA4)-inducibl...

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Detalles Bibliográficos
Autores principales:	Qi, Yuan-yuan, Zhao, Xin-yu, Liu, Xin-ran, Wang, Yan-na, Zhai, Ya-ling, Zhang, Xiao-xue, Wang, Xiao-yang, Zhang, Li-jie, Zhao, Ya-fei, Cui, Yan, Ning, Xiang-hui, Zhou, Xu-jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567630/ https://www.ncbi.nlm.nih.gov/pubmed/34736521 http://dx.doi.org/10.1186/s13075-021-02664-y

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