Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer

BACKGROUND: The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) cancer remains elusive. METHODS: This study retrospectively...

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Detalles Bibliográficos
Autores principales: Lu, Zhihao, Chen, Huan, Jiao, Xi, Wang, Yujiao, Wu, Lijia, Sun, Huaibo, Li, Shuang, Gong, Jifang, Li, Jian, Zou, Jianling, Yang, Keyan, Hu, Ying, Mao, Beibei, Zhang, Lei, Zhang, Xiaotian, Peng, Zhi, Lu, Ming, Wang, Zhenghang, Zhang, Henghui, Shen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567649/
https://www.ncbi.nlm.nih.gov/pubmed/34732240
http://dx.doi.org/10.1186/s13073-021-00997-6

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