The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes

Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if le...

Descripción completa

Detalles Bibliográficos
Autores principales: Payandeh, Zahra, Pirpour Tazehkand, Abbas, Azargoonjahromi, Ali, Almasi, Faezeh, Alagheband Bahrami, Armina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567674/
https://www.ncbi.nlm.nih.gov/pubmed/34736402
http://dx.doi.org/10.1186/s12575-021-00158-4
_version_ 1784594283136811008
author Payandeh, Zahra
Pirpour Tazehkand, Abbas
Azargoonjahromi, Ali
Almasi, Faezeh
Alagheband Bahrami, Armina
author_facet Payandeh, Zahra
Pirpour Tazehkand, Abbas
Azargoonjahromi, Ali
Almasi, Faezeh
Alagheband Bahrami, Armina
author_sort Payandeh, Zahra
collection PubMed
description Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if left untreated or being under continual external stimulation, could result in chronic inflammation, joint injury, and disability. T- and B-cells, signaling molecules, proinflammatory mediators, and synovium-specific targets are among the new therapeutic targets. Exosomes could be employed as therapeutic vectors in the treatment of autoimmune diseases. Herein, the role of cell organelle particularly exosomes in Rheumatoid Arthritis had discussed and some therapeutic applications of exosome highlighted.
format Online
Article
Text
id pubmed-8567674
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-85676742021-11-04 The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes Payandeh, Zahra Pirpour Tazehkand, Abbas Azargoonjahromi, Ali Almasi, Faezeh Alagheband Bahrami, Armina Biol Proced Online Review Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if left untreated or being under continual external stimulation, could result in chronic inflammation, joint injury, and disability. T- and B-cells, signaling molecules, proinflammatory mediators, and synovium-specific targets are among the new therapeutic targets. Exosomes could be employed as therapeutic vectors in the treatment of autoimmune diseases. Herein, the role of cell organelle particularly exosomes in Rheumatoid Arthritis had discussed and some therapeutic applications of exosome highlighted. BioMed Central 2021-11-04 /pmc/articles/PMC8567674/ /pubmed/34736402 http://dx.doi.org/10.1186/s12575-021-00158-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Payandeh, Zahra
Pirpour Tazehkand, Abbas
Azargoonjahromi, Ali
Almasi, Faezeh
Alagheband Bahrami, Armina
The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_full The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_fullStr The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_full_unstemmed The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_short The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_sort role of cell organelles in rheumatoid arthritis with focus on exosomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567674/
https://www.ncbi.nlm.nih.gov/pubmed/34736402
http://dx.doi.org/10.1186/s12575-021-00158-4
work_keys_str_mv AT payandehzahra theroleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT pirpourtazehkandabbas theroleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT azargoonjahromiali theroleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT almasifaezeh theroleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT alaghebandbahramiarmina theroleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT payandehzahra roleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT pirpourtazehkandabbas roleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT azargoonjahromiali roleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT almasifaezeh roleofcellorganellesinrheumatoidarthritiswithfocusonexosomes
AT alaghebandbahramiarmina roleofcellorganellesinrheumatoidarthritiswithfocusonexosomes

Ejemplares similares