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Sympathetic nerve-adipocyte interactions in response to acute stress

Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated...

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Autores principales: Santos, Gabryella S. P., Costa, Alinne C., Picoli, Caroline C., Rocha, Beatriz G. S., Sulaiman, Sheu O., Radicchi, Debora C., Pinto, Mauro C. X., Batista, Miguel L., Amorim, Jaime H., Azevedo, Vasco A. C., Resende, Rodrigo R., Câmara, Niels O. S., Mintz, Akiva, Birbrair, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567732/
https://www.ncbi.nlm.nih.gov/pubmed/34735579
http://dx.doi.org/10.1007/s00109-021-02157-0
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author Santos, Gabryella S. P.
Costa, Alinne C.
Picoli, Caroline C.
Rocha, Beatriz G. S.
Sulaiman, Sheu O.
Radicchi, Debora C.
Pinto, Mauro C. X.
Batista, Miguel L.
Amorim, Jaime H.
Azevedo, Vasco A. C.
Resende, Rodrigo R.
Câmara, Niels O. S.
Mintz, Akiva
Birbrair, Alexander
author_facet Santos, Gabryella S. P.
Costa, Alinne C.
Picoli, Caroline C.
Rocha, Beatriz G. S.
Sulaiman, Sheu O.
Radicchi, Debora C.
Pinto, Mauro C. X.
Batista, Miguel L.
Amorim, Jaime H.
Azevedo, Vasco A. C.
Resende, Rodrigo R.
Câmara, Niels O. S.
Mintz, Akiva
Birbrair, Alexander
author_sort Santos, Gabryella S. P.
collection PubMed
description Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment.
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spelling pubmed-85677322021-11-05 Sympathetic nerve-adipocyte interactions in response to acute stress Santos, Gabryella S. P. Costa, Alinne C. Picoli, Caroline C. Rocha, Beatriz G. S. Sulaiman, Sheu O. Radicchi, Debora C. Pinto, Mauro C. X. Batista, Miguel L. Amorim, Jaime H. Azevedo, Vasco A. C. Resende, Rodrigo R. Câmara, Niels O. S. Mintz, Akiva Birbrair, Alexander J Mol Med (Berl) Review Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment. Springer Berlin Heidelberg 2021-11-04 2022 /pmc/articles/PMC8567732/ /pubmed/34735579 http://dx.doi.org/10.1007/s00109-021-02157-0 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Santos, Gabryella S. P.
Costa, Alinne C.
Picoli, Caroline C.
Rocha, Beatriz G. S.
Sulaiman, Sheu O.
Radicchi, Debora C.
Pinto, Mauro C. X.
Batista, Miguel L.
Amorim, Jaime H.
Azevedo, Vasco A. C.
Resende, Rodrigo R.
Câmara, Niels O. S.
Mintz, Akiva
Birbrair, Alexander
Sympathetic nerve-adipocyte interactions in response to acute stress
title Sympathetic nerve-adipocyte interactions in response to acute stress
title_full Sympathetic nerve-adipocyte interactions in response to acute stress
title_fullStr Sympathetic nerve-adipocyte interactions in response to acute stress
title_full_unstemmed Sympathetic nerve-adipocyte interactions in response to acute stress
title_short Sympathetic nerve-adipocyte interactions in response to acute stress
title_sort sympathetic nerve-adipocyte interactions in response to acute stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567732/
https://www.ncbi.nlm.nih.gov/pubmed/34735579
http://dx.doi.org/10.1007/s00109-021-02157-0
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