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Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study

Significant genetic association exists between rheumatoid arthritis (RA) and cardiovascular disease. The associated mechanisms include common inflammatory mediators, changes in lipoprotein composition and function, immune responses, etc. However, the causality of RA and vascular/heart problems remai...

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Autores principales: Qiu, Shizheng, Li, Meijie, Jin, Shunshan, Lu, Haoyu, Hu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567962/
https://www.ncbi.nlm.nih.gov/pubmed/34745219
http://dx.doi.org/10.3389/fgene.2021.745224
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author Qiu, Shizheng
Li, Meijie
Jin, Shunshan
Lu, Haoyu
Hu, Yang
author_facet Qiu, Shizheng
Li, Meijie
Jin, Shunshan
Lu, Haoyu
Hu, Yang
author_sort Qiu, Shizheng
collection PubMed
description Significant genetic association exists between rheumatoid arthritis (RA) and cardiovascular disease. The associated mechanisms include common inflammatory mediators, changes in lipoprotein composition and function, immune responses, etc. However, the causality of RA and vascular/heart problems remains unknown. Herein, we performed Mendelian randomization (MR) analysis using a large-scale RA genome-wide association study (GWAS) dataset (462,933 cases and 457,732 controls) and six cardio-cerebrovascular disease GWAS datasets, including age angina (461,880 cases and 447,052 controls), hypertension (461,880 cases and 337,653 controls), age heart attack (10,693 cases and 451,187 controls), abnormalities of heartbeat (461,880 cases and 361,194 controls), stroke (7,055 cases and 454,825 controls), and coronary heart disease (361,194 cases and 351,037 controls) from United Kingdom biobank. We further carried out heterogeneity and sensitivity analyses. We confirmed the causality of RA with age angina (OR = 1.17, 95% CI: 1.04–1.33, p = 1.07E−02), hypertension (OR = 1.45, 95% CI: 1.20–1.75, p = 9.64E−05), age heart attack (OR = 1.15, 95% CI: 1.05–1.26, p = 3.56E−03), abnormalities of heartbeat (OR = 1.07, 95% CI: 1.01–1.12, p = 1.49E−02), stroke (OR = 1.06, 95% CI: 1.01–1.12, p = 2.79E−02), and coronary heart disease (OR = 1.19, 95% CI: 1.01–1.39, p = 3.33E−02), contributing to the understanding of the overlapping genetic mechanisms and therapeutic approaches between RA and cardiovascular disease.
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spelling pubmed-85679622021-11-05 Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study Qiu, Shizheng Li, Meijie Jin, Shunshan Lu, Haoyu Hu, Yang Front Genet Genetics Significant genetic association exists between rheumatoid arthritis (RA) and cardiovascular disease. The associated mechanisms include common inflammatory mediators, changes in lipoprotein composition and function, immune responses, etc. However, the causality of RA and vascular/heart problems remains unknown. Herein, we performed Mendelian randomization (MR) analysis using a large-scale RA genome-wide association study (GWAS) dataset (462,933 cases and 457,732 controls) and six cardio-cerebrovascular disease GWAS datasets, including age angina (461,880 cases and 447,052 controls), hypertension (461,880 cases and 337,653 controls), age heart attack (10,693 cases and 451,187 controls), abnormalities of heartbeat (461,880 cases and 361,194 controls), stroke (7,055 cases and 454,825 controls), and coronary heart disease (361,194 cases and 351,037 controls) from United Kingdom biobank. We further carried out heterogeneity and sensitivity analyses. We confirmed the causality of RA with age angina (OR = 1.17, 95% CI: 1.04–1.33, p = 1.07E−02), hypertension (OR = 1.45, 95% CI: 1.20–1.75, p = 9.64E−05), age heart attack (OR = 1.15, 95% CI: 1.05–1.26, p = 3.56E−03), abnormalities of heartbeat (OR = 1.07, 95% CI: 1.01–1.12, p = 1.49E−02), stroke (OR = 1.06, 95% CI: 1.01–1.12, p = 2.79E−02), and coronary heart disease (OR = 1.19, 95% CI: 1.01–1.39, p = 3.33E−02), contributing to the understanding of the overlapping genetic mechanisms and therapeutic approaches between RA and cardiovascular disease. Frontiers Media S.A. 2021-10-21 /pmc/articles/PMC8567962/ /pubmed/34745219 http://dx.doi.org/10.3389/fgene.2021.745224 Text en Copyright © 2021 Qiu, Li, Jin, Lu and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Qiu, Shizheng
Li, Meijie
Jin, Shunshan
Lu, Haoyu
Hu, Yang
Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study
title Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study
title_full Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study
title_fullStr Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study
title_full_unstemmed Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study
title_short Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study
title_sort rheumatoid arthritis and cardio-cerebrovascular disease: a mendelian randomization study
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567962/
https://www.ncbi.nlm.nih.gov/pubmed/34745219
http://dx.doi.org/10.3389/fgene.2021.745224
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