Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis

Metformin is one of the most widely prescribed medications for type 2 diabetes. While extremely rare, metformin has been reported to cause hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. In this paper, we present a case of a patient with previously undiagnosed glucose-6-phos...

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Detalles Bibliográficos
Autores principales: Roy Choudhury, Avijoy, Gadaga, Cecilia, Moodley, Layuren, Moodley, Aru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568038/
https://www.ncbi.nlm.nih.gov/pubmed/34754666
http://dx.doi.org/10.7759/cureus.18506
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author Roy Choudhury, Avijoy
Gadaga, Cecilia
Moodley, Layuren
Moodley, Aru
author_facet Roy Choudhury, Avijoy
Gadaga, Cecilia
Moodley, Layuren
Moodley, Aru
author_sort Roy Choudhury, Avijoy
collection PubMed
description Metformin is one of the most widely prescribed medications for type 2 diabetes. While extremely rare, metformin has been reported to cause hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. In this paper, we present a case of a patient with previously undiagnosed glucose-6-phosphate dehydrogenase deficiency who presented with hemolysis likely induced by metformin. The patient concurrently presented with idiopathic Steven-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Metformin causing hemolysis is extremely rare but considering the severe outcomes, it is something that medical practitioners need to be aware of.
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spelling pubmed-85680382021-11-08 Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis Roy Choudhury, Avijoy Gadaga, Cecilia Moodley, Layuren Moodley, Aru Cureus Internal Medicine Metformin is one of the most widely prescribed medications for type 2 diabetes. While extremely rare, metformin has been reported to cause hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. In this paper, we present a case of a patient with previously undiagnosed glucose-6-phosphate dehydrogenase deficiency who presented with hemolysis likely induced by metformin. The patient concurrently presented with idiopathic Steven-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Metformin causing hemolysis is extremely rare but considering the severe outcomes, it is something that medical practitioners need to be aware of. Cureus 2021-10-05 /pmc/articles/PMC8568038/ /pubmed/34754666 http://dx.doi.org/10.7759/cureus.18506 Text en Copyright © 2021, Roy Choudhury et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Roy Choudhury, Avijoy
Gadaga, Cecilia
Moodley, Layuren
Moodley, Aru
Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis
title Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis
title_full Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis
title_fullStr Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis
title_full_unstemmed Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis
title_short Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis
title_sort metformin-induced hemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency presenting with concurrent idiopathic steven-johnson syndrome/toxic epidermal necrolysis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568038/
https://www.ncbi.nlm.nih.gov/pubmed/34754666
http://dx.doi.org/10.7759/cureus.18506
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