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Development of at-home sample collection logistics for large-scale seroprevalence studies

BACKGROUND: Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic. METHODS: We aimed to design and implement a fully remote methodology for conducting safe serological surveys that als...

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Autores principales: Aatresh, Aishani V., Cummings, Kate, Gerstein, Hilary, Knight, Christopher S., Limberopolous, Andreas, Stasi, Megan A., Bedugnis, Alice, Somberg, Kenneth A., França, Camila T., Mina, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568136/
https://www.ncbi.nlm.nih.gov/pubmed/34735477
http://dx.doi.org/10.1371/journal.pone.0258516
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author Aatresh, Aishani V.
Cummings, Kate
Gerstein, Hilary
Knight, Christopher S.
Limberopolous, Andreas
Stasi, Megan A.
Bedugnis, Alice
Somberg, Kenneth A.
França, Camila T.
Mina, Michael J.
author_facet Aatresh, Aishani V.
Cummings, Kate
Gerstein, Hilary
Knight, Christopher S.
Limberopolous, Andreas
Stasi, Megan A.
Bedugnis, Alice
Somberg, Kenneth A.
França, Camila T.
Mina, Michael J.
author_sort Aatresh, Aishani V.
collection PubMed
description BACKGROUND: Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic. METHODS: We aimed to design and implement a fully remote methodology for conducting safe serological surveys that also allow for the engagement of representative study populations. RESULTS: This design was well-received and effective. 2,066 participants ≥18 years old were enrolled, reflecting the ethnic and racial composition of Massachusetts. >70% of them reported being satisfied/extremely satisfied with the online enrollment and at-home self-collection of blood samples. While 18.6% reported some discomfort experienced with the collection process, 72.2% stated that they would be willing to test weekly if enrolled in a long-term study. CONCLUSIONS: High engagement and positive feedback from participants, as well as the quality of self-collected specimens, point to the usefulness of this fully remote, self-collection-based study design for future safer and efficient population-level serological surveys.
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spelling pubmed-85681362021-11-05 Development of at-home sample collection logistics for large-scale seroprevalence studies Aatresh, Aishani V. Cummings, Kate Gerstein, Hilary Knight, Christopher S. Limberopolous, Andreas Stasi, Megan A. Bedugnis, Alice Somberg, Kenneth A. França, Camila T. Mina, Michael J. PLoS One Research Article BACKGROUND: Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic. METHODS: We aimed to design and implement a fully remote methodology for conducting safe serological surveys that also allow for the engagement of representative study populations. RESULTS: This design was well-received and effective. 2,066 participants ≥18 years old were enrolled, reflecting the ethnic and racial composition of Massachusetts. >70% of them reported being satisfied/extremely satisfied with the online enrollment and at-home self-collection of blood samples. While 18.6% reported some discomfort experienced with the collection process, 72.2% stated that they would be willing to test weekly if enrolled in a long-term study. CONCLUSIONS: High engagement and positive feedback from participants, as well as the quality of self-collected specimens, point to the usefulness of this fully remote, self-collection-based study design for future safer and efficient population-level serological surveys. Public Library of Science 2021-11-04 /pmc/articles/PMC8568136/ /pubmed/34735477 http://dx.doi.org/10.1371/journal.pone.0258516 Text en © 2021 Aatresh et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Aatresh, Aishani V.
Cummings, Kate
Gerstein, Hilary
Knight, Christopher S.
Limberopolous, Andreas
Stasi, Megan A.
Bedugnis, Alice
Somberg, Kenneth A.
França, Camila T.
Mina, Michael J.
Development of at-home sample collection logistics for large-scale seroprevalence studies
title Development of at-home sample collection logistics for large-scale seroprevalence studies
title_full Development of at-home sample collection logistics for large-scale seroprevalence studies
title_fullStr Development of at-home sample collection logistics for large-scale seroprevalence studies
title_full_unstemmed Development of at-home sample collection logistics for large-scale seroprevalence studies
title_short Development of at-home sample collection logistics for large-scale seroprevalence studies
title_sort development of at-home sample collection logistics for large-scale seroprevalence studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568136/
https://www.ncbi.nlm.nih.gov/pubmed/34735477
http://dx.doi.org/10.1371/journal.pone.0258516
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