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Plasma circulating cell-free mitochondrial DNA in depressive disorders
BACKGROUND: Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic molecule and a novel biomarker of psychiatric disorders. Some previous studies reported increased levels of ccf-mtDNA in unmedicated depression and recent suicide attempters, while other studies found unchanged...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568274/ https://www.ncbi.nlm.nih.gov/pubmed/34735532 http://dx.doi.org/10.1371/journal.pone.0259591 |
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author | Fernström, Johan Ohlsson, Lars Asp, Marie Lavant, Eva Holck, Amanda Grudet, Cécile Westrin, Åsa Lindqvist, Daniel |
author_facet | Fernström, Johan Ohlsson, Lars Asp, Marie Lavant, Eva Holck, Amanda Grudet, Cécile Westrin, Åsa Lindqvist, Daniel |
author_sort | Fernström, Johan |
collection | PubMed |
description | BACKGROUND: Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic molecule and a novel biomarker of psychiatric disorders. Some previous studies reported increased levels of ccf-mtDNA in unmedicated depression and recent suicide attempters, while other studies found unchanged or decreased ccf-mtDNA levels in depression. Inconsistent findings across studies may be explained by small sample sizes and between-study variations in somatic and psychiatric co-morbidity or medication status. METHODS: We measured plasma ccf-mtDNA in a cohort of 281 patients with depressive disorders and 49 healthy controls. Ninety-three percent of all patients were treated with one or several psychotropic medications. Thirty-six percent had a personality disorder, 13% bipolar disorder. All analyses involving ccf-mtDNA were a priori adjusted for age and sex. RESULTS: Mean levels in ccf-mtDNA were significantly different between patients with a current depressive episode (n = 236), remitted depressive episode (n = 45) and healthy controls (n = 49) (f = 8.3, p<0.001). Post-hoc tests revealed that both patients with current (p<0.001) and remitted (p = 0.002) depression had lower ccf-mtDNA compared to controls. Within the depressed group there was a positive correlation between ccf-mtDNA and “inflammatory depression symptoms” (r = 0.15, p = 0.02). We also found that treatment with mood stabilizers lamotrigine, valproic acid or lithium was associated with lower ccf-mtDNA (f = 8.1, p = 0.005). DISCUSSION: Decreased plasma ccf-mtDNA in difficult-to-treat depression may be partly explained by concurrent psychotropic medications and co-morbidity. Our findings suggest that ccf-mtDNA may be differentially regulated in different subtypes of depression, and this hypothesis should be pursued in future studies. |
format | Online Article Text |
id | pubmed-8568274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85682742021-11-05 Plasma circulating cell-free mitochondrial DNA in depressive disorders Fernström, Johan Ohlsson, Lars Asp, Marie Lavant, Eva Holck, Amanda Grudet, Cécile Westrin, Åsa Lindqvist, Daniel PLoS One Research Article BACKGROUND: Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic molecule and a novel biomarker of psychiatric disorders. Some previous studies reported increased levels of ccf-mtDNA in unmedicated depression and recent suicide attempters, while other studies found unchanged or decreased ccf-mtDNA levels in depression. Inconsistent findings across studies may be explained by small sample sizes and between-study variations in somatic and psychiatric co-morbidity or medication status. METHODS: We measured plasma ccf-mtDNA in a cohort of 281 patients with depressive disorders and 49 healthy controls. Ninety-three percent of all patients were treated with one or several psychotropic medications. Thirty-six percent had a personality disorder, 13% bipolar disorder. All analyses involving ccf-mtDNA were a priori adjusted for age and sex. RESULTS: Mean levels in ccf-mtDNA were significantly different between patients with a current depressive episode (n = 236), remitted depressive episode (n = 45) and healthy controls (n = 49) (f = 8.3, p<0.001). Post-hoc tests revealed that both patients with current (p<0.001) and remitted (p = 0.002) depression had lower ccf-mtDNA compared to controls. Within the depressed group there was a positive correlation between ccf-mtDNA and “inflammatory depression symptoms” (r = 0.15, p = 0.02). We also found that treatment with mood stabilizers lamotrigine, valproic acid or lithium was associated with lower ccf-mtDNA (f = 8.1, p = 0.005). DISCUSSION: Decreased plasma ccf-mtDNA in difficult-to-treat depression may be partly explained by concurrent psychotropic medications and co-morbidity. Our findings suggest that ccf-mtDNA may be differentially regulated in different subtypes of depression, and this hypothesis should be pursued in future studies. Public Library of Science 2021-11-04 /pmc/articles/PMC8568274/ /pubmed/34735532 http://dx.doi.org/10.1371/journal.pone.0259591 Text en © 2021 Fernström et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fernström, Johan Ohlsson, Lars Asp, Marie Lavant, Eva Holck, Amanda Grudet, Cécile Westrin, Åsa Lindqvist, Daniel Plasma circulating cell-free mitochondrial DNA in depressive disorders |
title | Plasma circulating cell-free mitochondrial DNA in depressive disorders |
title_full | Plasma circulating cell-free mitochondrial DNA in depressive disorders |
title_fullStr | Plasma circulating cell-free mitochondrial DNA in depressive disorders |
title_full_unstemmed | Plasma circulating cell-free mitochondrial DNA in depressive disorders |
title_short | Plasma circulating cell-free mitochondrial DNA in depressive disorders |
title_sort | plasma circulating cell-free mitochondrial dna in depressive disorders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568274/ https://www.ncbi.nlm.nih.gov/pubmed/34735532 http://dx.doi.org/10.1371/journal.pone.0259591 |
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