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Research Progress on Circular RNA in Glioma
The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure. They are highly expressed, spatiotemporal-specific and conservative across species. Importantly, circRNA participates in the occurr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568300/ https://www.ncbi.nlm.nih.gov/pubmed/34745938 http://dx.doi.org/10.3389/fonc.2021.705059 |
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author | Chen, Mengyu Yan, Chunyan Zhao, Xihe |
author_facet | Chen, Mengyu Yan, Chunyan Zhao, Xihe |
author_sort | Chen, Mengyu |
collection | PubMed |
description | The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure. They are highly expressed, spatiotemporal-specific and conservative across species. Importantly, circRNA participates in the occurrence of many kinds of tumors and regulates the tumor development. Glioma is featured by limited therapy and grim prognosis. Cancer-associated circRNA compromises original function or creates new effects in glioma, thus contributing to oncogenesis. Therefore, this article reviews the biogenesis, metabolism, functions and properties of circRNA as a novel potential biomarker for gliomas. We elaborate the expression characteristics, interaction between circRNA and other molecules, aiming to identify new targets for early diagnosis and treatment of gliomas. |
format | Online Article Text |
id | pubmed-8568300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85683002021-11-05 Research Progress on Circular RNA in Glioma Chen, Mengyu Yan, Chunyan Zhao, Xihe Front Oncol Oncology The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure. They are highly expressed, spatiotemporal-specific and conservative across species. Importantly, circRNA participates in the occurrence of many kinds of tumors and regulates the tumor development. Glioma is featured by limited therapy and grim prognosis. Cancer-associated circRNA compromises original function or creates new effects in glioma, thus contributing to oncogenesis. Therefore, this article reviews the biogenesis, metabolism, functions and properties of circRNA as a novel potential biomarker for gliomas. We elaborate the expression characteristics, interaction between circRNA and other molecules, aiming to identify new targets for early diagnosis and treatment of gliomas. Frontiers Media S.A. 2021-10-21 /pmc/articles/PMC8568300/ /pubmed/34745938 http://dx.doi.org/10.3389/fonc.2021.705059 Text en Copyright © 2021 Chen, Yan and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chen, Mengyu Yan, Chunyan Zhao, Xihe Research Progress on Circular RNA in Glioma |
title | Research Progress on Circular RNA in Glioma |
title_full | Research Progress on Circular RNA in Glioma |
title_fullStr | Research Progress on Circular RNA in Glioma |
title_full_unstemmed | Research Progress on Circular RNA in Glioma |
title_short | Research Progress on Circular RNA in Glioma |
title_sort | research progress on circular rna in glioma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568300/ https://www.ncbi.nlm.nih.gov/pubmed/34745938 http://dx.doi.org/10.3389/fonc.2021.705059 |
work_keys_str_mv | AT chenmengyu researchprogressoncircularrnainglioma AT yanchunyan researchprogressoncircularrnainglioma AT zhaoxihe researchprogressoncircularrnainglioma |