Cargando…

Emerging dynamics from high-resolution spatial numerical epidemics

Simulating nationwide realistic individual movements with a detailed geographical structure can help optimise public health policies. However, existing tools have limited resolution or can only account for a limited number of agents. We introduce Epidemap, a new framework that can capture the daily...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomine, Olivier, Alizon, Samuel, Boennec, Corentin, Barthelemy, Marc, Sofonea, Mircea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568339/
https://www.ncbi.nlm.nih.gov/pubmed/34652271
http://dx.doi.org/10.7554/eLife.71417
_version_ 1784594415774334976
author Thomine, Olivier
Alizon, Samuel
Boennec, Corentin
Barthelemy, Marc
Sofonea, Mircea
author_facet Thomine, Olivier
Alizon, Samuel
Boennec, Corentin
Barthelemy, Marc
Sofonea, Mircea
author_sort Thomine, Olivier
collection PubMed
description Simulating nationwide realistic individual movements with a detailed geographical structure can help optimise public health policies. However, existing tools have limited resolution or can only account for a limited number of agents. We introduce Epidemap, a new framework that can capture the daily movement of more than 60 million people in a country at a building-level resolution in a realistic and computationally efficient way. By applying it to the case of an infectious disease spreading in France, we uncover hitherto neglected effects, such as the emergence of two distinct peaks in the daily number of cases or the importance of local density in the timing of arrival of the epidemic. Finally, we show that the importance of super-spreading events strongly varies over time.
format Online
Article
Text
id pubmed-8568339
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-85683392021-11-08 Emerging dynamics from high-resolution spatial numerical epidemics Thomine, Olivier Alizon, Samuel Boennec, Corentin Barthelemy, Marc Sofonea, Mircea eLife Computational and Systems Biology Simulating nationwide realistic individual movements with a detailed geographical structure can help optimise public health policies. However, existing tools have limited resolution or can only account for a limited number of agents. We introduce Epidemap, a new framework that can capture the daily movement of more than 60 million people in a country at a building-level resolution in a realistic and computationally efficient way. By applying it to the case of an infectious disease spreading in France, we uncover hitherto neglected effects, such as the emergence of two distinct peaks in the daily number of cases or the importance of local density in the timing of arrival of the epidemic. Finally, we show that the importance of super-spreading events strongly varies over time. eLife Sciences Publications, Ltd 2021-10-15 /pmc/articles/PMC8568339/ /pubmed/34652271 http://dx.doi.org/10.7554/eLife.71417 Text en © 2021, Thomine et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Thomine, Olivier
Alizon, Samuel
Boennec, Corentin
Barthelemy, Marc
Sofonea, Mircea
Emerging dynamics from high-resolution spatial numerical epidemics
title Emerging dynamics from high-resolution spatial numerical epidemics
title_full Emerging dynamics from high-resolution spatial numerical epidemics
title_fullStr Emerging dynamics from high-resolution spatial numerical epidemics
title_full_unstemmed Emerging dynamics from high-resolution spatial numerical epidemics
title_short Emerging dynamics from high-resolution spatial numerical epidemics
title_sort emerging dynamics from high-resolution spatial numerical epidemics
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568339/
https://www.ncbi.nlm.nih.gov/pubmed/34652271
http://dx.doi.org/10.7554/eLife.71417
work_keys_str_mv AT thomineolivier emergingdynamicsfromhighresolutionspatialnumericalepidemics
AT alizonsamuel emergingdynamicsfromhighresolutionspatialnumericalepidemics
AT boenneccorentin emergingdynamicsfromhighresolutionspatialnumericalepidemics
AT barthelemymarc emergingdynamicsfromhighresolutionspatialnumericalepidemics
AT sofoneamircea emergingdynamicsfromhighresolutionspatialnumericalepidemics