Cargando…

New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments

The bone microenvironment is characterized by an intricate interplay between cellular and noncellular components, which controls bone remodeling and repair. Its highly hierarchical architecture and dynamic composition provide a unique microenvironment as source of inspiration for the design of a wid...

Descripción completa

Detalles Bibliográficos
Autores principales: Oliveira, Cláudia S., Leeuwenburgh, Sander, Mano, João F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568480/
https://www.ncbi.nlm.nih.gov/pubmed/34765857
http://dx.doi.org/10.1063/5.0065152
_version_ 1784594449465081856
author Oliveira, Cláudia S.
Leeuwenburgh, Sander
Mano, João F.
author_facet Oliveira, Cláudia S.
Leeuwenburgh, Sander
Mano, João F.
author_sort Oliveira, Cláudia S.
collection PubMed
description The bone microenvironment is characterized by an intricate interplay between cellular and noncellular components, which controls bone remodeling and repair. Its highly hierarchical architecture and dynamic composition provide a unique microenvironment as source of inspiration for the design of a wide variety of bone tissue engineering strategies. To overcome current limitations associated with the gold standard for the treatment of bone fractures and defects, bioengineered bone microenvironments have the potential to orchestrate the process of bone regeneration in a self-regulated manner. However, successful approaches require a strategic combination of osteogenic, vasculogenic, and immunomodulatory factors through a synergic coordination between bone cells, bone-forming factors, and biomaterials. Herein, we provide an overview of (i) current three-dimensional strategies that mimic the bone microenvironment and (ii) potential applications of bioengineered microenvironments. These strategies range from simple to highly complex, aiming to recreate the architecture and spatial organization of cell–cell, cell-matrix, and cell-soluble factor interactions resembling the in vivo microenvironment. While several bone microenvironment-mimicking strategies with biophysical and biochemical cues have been proposed, approaches that exploit the ability of the cells to self-organize into microenvironments with a high regenerative capacity should become a top priority in the design of strategies toward bone regeneration. These miniaturized bone platforms may recapitulate key characteristics of the bone regenerative process and hold great promise to provide new treatment concepts for the next generation of bone implants.
format Online
Article
Text
id pubmed-8568480
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher AIP Publishing LLC
record_format MEDLINE/PubMed
spelling pubmed-85684802021-11-10 New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments Oliveira, Cláudia S. Leeuwenburgh, Sander Mano, João F. APL Bioeng Reviews The bone microenvironment is characterized by an intricate interplay between cellular and noncellular components, which controls bone remodeling and repair. Its highly hierarchical architecture and dynamic composition provide a unique microenvironment as source of inspiration for the design of a wide variety of bone tissue engineering strategies. To overcome current limitations associated with the gold standard for the treatment of bone fractures and defects, bioengineered bone microenvironments have the potential to orchestrate the process of bone regeneration in a self-regulated manner. However, successful approaches require a strategic combination of osteogenic, vasculogenic, and immunomodulatory factors through a synergic coordination between bone cells, bone-forming factors, and biomaterials. Herein, we provide an overview of (i) current three-dimensional strategies that mimic the bone microenvironment and (ii) potential applications of bioengineered microenvironments. These strategies range from simple to highly complex, aiming to recreate the architecture and spatial organization of cell–cell, cell-matrix, and cell-soluble factor interactions resembling the in vivo microenvironment. While several bone microenvironment-mimicking strategies with biophysical and biochemical cues have been proposed, approaches that exploit the ability of the cells to self-organize into microenvironments with a high regenerative capacity should become a top priority in the design of strategies toward bone regeneration. These miniaturized bone platforms may recapitulate key characteristics of the bone regenerative process and hold great promise to provide new treatment concepts for the next generation of bone implants. AIP Publishing LLC 2021-11-03 /pmc/articles/PMC8568480/ /pubmed/34765857 http://dx.doi.org/10.1063/5.0065152 Text en © 2021 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Reviews
Oliveira, Cláudia S.
Leeuwenburgh, Sander
Mano, João F.
New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
title New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
title_full New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
title_fullStr New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
title_full_unstemmed New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
title_short New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
title_sort new insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568480/
https://www.ncbi.nlm.nih.gov/pubmed/34765857
http://dx.doi.org/10.1063/5.0065152
work_keys_str_mv AT oliveiraclaudias newinsightsintothebiomimeticdesignandbiomedicalapplicationsofbioengineeredbonemicroenvironments
AT leeuwenburghsander newinsightsintothebiomimeticdesignandbiomedicalapplicationsofbioengineeredbonemicroenvironments
AT manojoaof newinsightsintothebiomimeticdesignandbiomedicalapplicationsofbioengineeredbonemicroenvironments