Cargando…
New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments
The bone microenvironment is characterized by an intricate interplay between cellular and noncellular components, which controls bone remodeling and repair. Its highly hierarchical architecture and dynamic composition provide a unique microenvironment as source of inspiration for the design of a wid...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568480/ https://www.ncbi.nlm.nih.gov/pubmed/34765857 http://dx.doi.org/10.1063/5.0065152 |
_version_ | 1784594449465081856 |
---|---|
author | Oliveira, Cláudia S. Leeuwenburgh, Sander Mano, João F. |
author_facet | Oliveira, Cláudia S. Leeuwenburgh, Sander Mano, João F. |
author_sort | Oliveira, Cláudia S. |
collection | PubMed |
description | The bone microenvironment is characterized by an intricate interplay between cellular and noncellular components, which controls bone remodeling and repair. Its highly hierarchical architecture and dynamic composition provide a unique microenvironment as source of inspiration for the design of a wide variety of bone tissue engineering strategies. To overcome current limitations associated with the gold standard for the treatment of bone fractures and defects, bioengineered bone microenvironments have the potential to orchestrate the process of bone regeneration in a self-regulated manner. However, successful approaches require a strategic combination of osteogenic, vasculogenic, and immunomodulatory factors through a synergic coordination between bone cells, bone-forming factors, and biomaterials. Herein, we provide an overview of (i) current three-dimensional strategies that mimic the bone microenvironment and (ii) potential applications of bioengineered microenvironments. These strategies range from simple to highly complex, aiming to recreate the architecture and spatial organization of cell–cell, cell-matrix, and cell-soluble factor interactions resembling the in vivo microenvironment. While several bone microenvironment-mimicking strategies with biophysical and biochemical cues have been proposed, approaches that exploit the ability of the cells to self-organize into microenvironments with a high regenerative capacity should become a top priority in the design of strategies toward bone regeneration. These miniaturized bone platforms may recapitulate key characteristics of the bone regenerative process and hold great promise to provide new treatment concepts for the next generation of bone implants. |
format | Online Article Text |
id | pubmed-8568480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-85684802021-11-10 New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments Oliveira, Cláudia S. Leeuwenburgh, Sander Mano, João F. APL Bioeng Reviews The bone microenvironment is characterized by an intricate interplay between cellular and noncellular components, which controls bone remodeling and repair. Its highly hierarchical architecture and dynamic composition provide a unique microenvironment as source of inspiration for the design of a wide variety of bone tissue engineering strategies. To overcome current limitations associated with the gold standard for the treatment of bone fractures and defects, bioengineered bone microenvironments have the potential to orchestrate the process of bone regeneration in a self-regulated manner. However, successful approaches require a strategic combination of osteogenic, vasculogenic, and immunomodulatory factors through a synergic coordination between bone cells, bone-forming factors, and biomaterials. Herein, we provide an overview of (i) current three-dimensional strategies that mimic the bone microenvironment and (ii) potential applications of bioengineered microenvironments. These strategies range from simple to highly complex, aiming to recreate the architecture and spatial organization of cell–cell, cell-matrix, and cell-soluble factor interactions resembling the in vivo microenvironment. While several bone microenvironment-mimicking strategies with biophysical and biochemical cues have been proposed, approaches that exploit the ability of the cells to self-organize into microenvironments with a high regenerative capacity should become a top priority in the design of strategies toward bone regeneration. These miniaturized bone platforms may recapitulate key characteristics of the bone regenerative process and hold great promise to provide new treatment concepts for the next generation of bone implants. AIP Publishing LLC 2021-11-03 /pmc/articles/PMC8568480/ /pubmed/34765857 http://dx.doi.org/10.1063/5.0065152 Text en © 2021 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Reviews Oliveira, Cláudia S. Leeuwenburgh, Sander Mano, João F. New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments |
title | New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments |
title_full | New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments |
title_fullStr | New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments |
title_full_unstemmed | New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments |
title_short | New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments |
title_sort | new insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568480/ https://www.ncbi.nlm.nih.gov/pubmed/34765857 http://dx.doi.org/10.1063/5.0065152 |
work_keys_str_mv | AT oliveiraclaudias newinsightsintothebiomimeticdesignandbiomedicalapplicationsofbioengineeredbonemicroenvironments AT leeuwenburghsander newinsightsintothebiomimeticdesignandbiomedicalapplicationsofbioengineeredbonemicroenvironments AT manojoaof newinsightsintothebiomimeticdesignandbiomedicalapplicationsofbioengineeredbonemicroenvironments |