MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders

The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in...

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Detalles Bibliográficos
Autores principales: Yu, Yang, Liu, Dan-yang, Chen, Xue-shen, Zhu, Ling, Wan, Li-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568515/
https://www.ncbi.nlm.nih.gov/pubmed/34745419
http://dx.doi.org/10.1155/2021/6467679
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author Yu, Yang
Liu, Dan-yang
Chen, Xue-shen
Zhu, Ling
Wan, Li-hong
author_facet Yu, Yang
Liu, Dan-yang
Chen, Xue-shen
Zhu, Ling
Wan, Li-hong
author_sort Yu, Yang
collection PubMed
description The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in many ER stress-related diseases with a protective effect. Here, we review the function of MANF based on its structure in neurological and metabolic disorders and summarize its potential applications in disease diagnosis and therapies.
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spelling pubmed-85685152021-11-05 MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders Yu, Yang Liu, Dan-yang Chen, Xue-shen Zhu, Ling Wan, Li-hong Oxid Med Cell Longev Review Article The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in many ER stress-related diseases with a protective effect. Here, we review the function of MANF based on its structure in neurological and metabolic disorders and summarize its potential applications in disease diagnosis and therapies. Hindawi 2021-10-28 /pmc/articles/PMC8568515/ /pubmed/34745419 http://dx.doi.org/10.1155/2021/6467679 Text en Copyright © 2021 Yang Yu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yu, Yang
Liu, Dan-yang
Chen, Xue-shen
Zhu, Ling
Wan, Li-hong
MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_full MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_fullStr MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_full_unstemmed MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_short MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_sort manf: a novel endoplasmic reticulum stress response protein—the role in neurological and metabolic disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568515/
https://www.ncbi.nlm.nih.gov/pubmed/34745419
http://dx.doi.org/10.1155/2021/6467679
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