The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A

The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation m...

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Detalles Bibliográficos
Autores principales: Sun, Weiwei, Zhang, Bin, Bie, Qingli, Ma, Na, Liu, Na, Shao, Zewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568546/
https://www.ncbi.nlm.nih.gov/pubmed/34745269
http://dx.doi.org/10.1155/2021/8874360
Descripción
Sumario:The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation modifications including N6-methyladenosine, 5-methylcytosine, and uridylation in embryonic stem cells, adult stem cells, induced pluripotent stem cells, and cancer stem cells, so as to provide new insights into the potential innovative treatments of cancer or other complex diseases.

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