The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A

The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation m...

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Detalles Bibliográficos
Autores principales: Sun, Weiwei, Zhang, Bin, Bie, Qingli, Ma, Na, Liu, Na, Shao, Zewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568546/
https://www.ncbi.nlm.nih.gov/pubmed/34745269
http://dx.doi.org/10.1155/2021/8874360
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author Sun, Weiwei
Zhang, Bin
Bie, Qingli
Ma, Na
Liu, Na
Shao, Zewei
author_facet Sun, Weiwei
Zhang, Bin
Bie, Qingli
Ma, Na
Liu, Na
Shao, Zewei
author_sort Sun, Weiwei
collection PubMed
description The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation modifications including N6-methyladenosine, 5-methylcytosine, and uridylation in embryonic stem cells, adult stem cells, induced pluripotent stem cells, and cancer stem cells, so as to provide new insights into the potential innovative treatments of cancer or other complex diseases.
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spelling pubmed-85685462021-11-05 The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A Sun, Weiwei Zhang, Bin Bie, Qingli Ma, Na Liu, Na Shao, Zewei Stem Cells Int Review Article The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation modifications including N6-methyladenosine, 5-methylcytosine, and uridylation in embryonic stem cells, adult stem cells, induced pluripotent stem cells, and cancer stem cells, so as to provide new insights into the potential innovative treatments of cancer or other complex diseases. Hindawi 2021-10-28 /pmc/articles/PMC8568546/ /pubmed/34745269 http://dx.doi.org/10.1155/2021/8874360 Text en Copyright © 2021 Weiwei Sun et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sun, Weiwei
Zhang, Bin
Bie, Qingli
Ma, Na
Liu, Na
Shao, Zewei
The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A
title The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A
title_full The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A
title_fullStr The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A
title_full_unstemmed The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A
title_short The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m(6)A
title_sort role of rna methylation in regulating stem cell fate and function-focus on m(6)a
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568546/
https://www.ncbi.nlm.nih.gov/pubmed/34745269
http://dx.doi.org/10.1155/2021/8874360
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