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Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy
Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and to show clearly its method of action, we managed and did an in-depth discussion. Network pharmacology research is very suitable for the analysis of multiple components, multiple targets, and multiple pathways of Tr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568550/ https://www.ncbi.nlm.nih.gov/pubmed/34745308 http://dx.doi.org/10.1155/2021/9888607 |
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author | Feipeng, Gong Luxin, Xie Beili, Chen Songhong, Yang Wenting, Wu Junmao, Li Qianfeng, Gong Lingyun, Zhong Jianxiong, Wu |
author_facet | Feipeng, Gong Luxin, Xie Beili, Chen Songhong, Yang Wenting, Wu Junmao, Li Qianfeng, Gong Lingyun, Zhong Jianxiong, Wu |
author_sort | Feipeng, Gong |
collection | PubMed |
description | Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and to show clearly its method of action, we managed and did an in-depth discussion. Network pharmacology research is very suitable for the analysis of multiple components, multiple targets, and multiple pathways of Traditional Chinese Medicine (TCM). According to the relevant theory, we first carefully collected and screened the active ingredients in ZSS and received 11 active ingredients that may work. The targets going along with these active components were also strongly related to insomnia targets, 108 common genes were identified, and drug-compound-gene symbol-disease visualization network and protein-protein interaction network were constructed. Forty-eight core genes were identified by PPI analysis and subjected to GO functional analysis with KEGG pathway analysis. The results of GO analysis pointed that there were 998 gene ontology items for the treatment of insomnia, including terms of 892 biological processes, 47 cellular components, and 59 molecular functions. It mainly shows the coupling effect and transport mode of some proteins in the biological pathways of ZSS in the treatment of insomnia and explains the mechanism of action through the connection between the target and the cell biomembrane. KEGG enrichment analyzed 19 signaling pathways, which were collectively classified into seven categories. We have identified the potential pathways of ZSS against insomnia and obtained the regulatory relationship between core genes and pathways and know that the same target can be regulated by multiple components at the same time. The results of molecular docking also prove this conclusion. We sought to provide a new analytical approach to explore TCM treatments for diseases using network pharmacology analysis tools. |
format | Online Article Text |
id | pubmed-8568550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85685502021-11-05 Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy Feipeng, Gong Luxin, Xie Beili, Chen Songhong, Yang Wenting, Wu Junmao, Li Qianfeng, Gong Lingyun, Zhong Jianxiong, Wu Evid Based Complement Alternat Med Research Article Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and to show clearly its method of action, we managed and did an in-depth discussion. Network pharmacology research is very suitable for the analysis of multiple components, multiple targets, and multiple pathways of Traditional Chinese Medicine (TCM). According to the relevant theory, we first carefully collected and screened the active ingredients in ZSS and received 11 active ingredients that may work. The targets going along with these active components were also strongly related to insomnia targets, 108 common genes were identified, and drug-compound-gene symbol-disease visualization network and protein-protein interaction network were constructed. Forty-eight core genes were identified by PPI analysis and subjected to GO functional analysis with KEGG pathway analysis. The results of GO analysis pointed that there were 998 gene ontology items for the treatment of insomnia, including terms of 892 biological processes, 47 cellular components, and 59 molecular functions. It mainly shows the coupling effect and transport mode of some proteins in the biological pathways of ZSS in the treatment of insomnia and explains the mechanism of action through the connection between the target and the cell biomembrane. KEGG enrichment analyzed 19 signaling pathways, which were collectively classified into seven categories. We have identified the potential pathways of ZSS against insomnia and obtained the regulatory relationship between core genes and pathways and know that the same target can be regulated by multiple components at the same time. The results of molecular docking also prove this conclusion. We sought to provide a new analytical approach to explore TCM treatments for diseases using network pharmacology analysis tools. Hindawi 2021-10-28 /pmc/articles/PMC8568550/ /pubmed/34745308 http://dx.doi.org/10.1155/2021/9888607 Text en Copyright © 2021 Gong Feipeng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Feipeng, Gong Luxin, Xie Beili, Chen Songhong, Yang Wenting, Wu Junmao, Li Qianfeng, Gong Lingyun, Zhong Jianxiong, Wu Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy |
title | Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy |
title_full | Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy |
title_fullStr | Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy |
title_full_unstemmed | Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy |
title_short | Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy |
title_sort | exploration of ziziphi spinosae semen in treating insomnia based on network pharmacology strategy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568550/ https://www.ncbi.nlm.nih.gov/pubmed/34745308 http://dx.doi.org/10.1155/2021/9888607 |
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