Cargando…

Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury

Objective: Traumatic brain injury (TBI) is a global public health problem. Hyperbaric oxygen (HBO) therapy may be beneficial for TBI because it improves cerebral blood flow into tissues exhibiting low blood flow. This was done to observe the clinical therapeutic effect of different intensities of re...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Yin, Zhou, Xianshan, Cheng, Jincheng, Ma, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568788/
https://www.ncbi.nlm.nih.gov/pubmed/34546088
http://dx.doi.org/10.1089/wound.2018.0876
_version_ 1784594504356986880
author Lu, Yin
Zhou, Xianshan
Cheng, Jincheng
Ma, Qing
author_facet Lu, Yin
Zhou, Xianshan
Cheng, Jincheng
Ma, Qing
author_sort Lu, Yin
collection PubMed
description Objective: Traumatic brain injury (TBI) is a global public health problem. Hyperbaric oxygen (HBO) therapy may be beneficial for TBI because it improves cerebral blood flow into tissues exhibiting low blood flow. This was done to observe the clinical therapeutic effect of different intensities of rehabilitation training and HBO therapy in early stages of TBI. Approach: In this multicenter, randomized, stratified case-controlled prospective clinical trial, we selected 158 patients with moderate-severe TBI and assigned them into (1) a control group receiving routine once-daily (1/d) rehabilitation training without HBO, (2) study group A receiving routine 1/d rehabilitation training with HBO, (3) study group B receiving twice-daily (2/d) intensified rehabilitation training with HBO, and (4) study group C receiving 2/d intensified rehabilitation training without HBO, all for 3 months. The cognitive ability, activities of daily life (ADL), and movement ability were assessed before and after training with the Fugl-Meyer Assessment (FMA), Functional Independence Measure (FIM), Modified Barthel Index (MBI), and Mini-Mental State Examination (MMSE). Results: FIM, FMA, MBI, and MMSE scores were improved significantly after 1-, 2-, and 3-month rehabilitation training in all TBI patients (p < 0.01), and this improvement was especially remarkable in patients who received 2/d intensified rehabilitation training with HBO (p < 0.01). Innovation: With extensive and intensive research on TBI rehabilitation, it was proved that TBI rehabilitation intervention should be initiated as early as possible. Conclusion: Early intensified rehabilitation training in combination with HBO is more beneficial to the recovery of cognitive, ADL, and movement abilities of TBI patients.
format Online
Article
Text
id pubmed-8568788
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Mary Ann Liebert, Inc., publishers
record_format MEDLINE/PubMed
spelling pubmed-85687882021-11-05 Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury Lu, Yin Zhou, Xianshan Cheng, Jincheng Ma, Qing Adv Wound Care (New Rochelle) Discovery Express Objective: Traumatic brain injury (TBI) is a global public health problem. Hyperbaric oxygen (HBO) therapy may be beneficial for TBI because it improves cerebral blood flow into tissues exhibiting low blood flow. This was done to observe the clinical therapeutic effect of different intensities of rehabilitation training and HBO therapy in early stages of TBI. Approach: In this multicenter, randomized, stratified case-controlled prospective clinical trial, we selected 158 patients with moderate-severe TBI and assigned them into (1) a control group receiving routine once-daily (1/d) rehabilitation training without HBO, (2) study group A receiving routine 1/d rehabilitation training with HBO, (3) study group B receiving twice-daily (2/d) intensified rehabilitation training with HBO, and (4) study group C receiving 2/d intensified rehabilitation training without HBO, all for 3 months. The cognitive ability, activities of daily life (ADL), and movement ability were assessed before and after training with the Fugl-Meyer Assessment (FMA), Functional Independence Measure (FIM), Modified Barthel Index (MBI), and Mini-Mental State Examination (MMSE). Results: FIM, FMA, MBI, and MMSE scores were improved significantly after 1-, 2-, and 3-month rehabilitation training in all TBI patients (p < 0.01), and this improvement was especially remarkable in patients who received 2/d intensified rehabilitation training with HBO (p < 0.01). Innovation: With extensive and intensive research on TBI rehabilitation, it was proved that TBI rehabilitation intervention should be initiated as early as possible. Conclusion: Early intensified rehabilitation training in combination with HBO is more beneficial to the recovery of cognitive, ADL, and movement abilities of TBI patients. Mary Ann Liebert, Inc., publishers 2021-12-01 2021-09-21 /pmc/articles/PMC8568788/ /pubmed/34546088 http://dx.doi.org/10.1089/wound.2018.0876 Text en © Yin Lu et al. 2021; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discovery Express
Lu, Yin
Zhou, Xianshan
Cheng, Jincheng
Ma, Qing
Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury
title Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury
title_full Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury
title_fullStr Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury
title_full_unstemmed Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury
title_short Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury
title_sort early intensified rehabilitation training with hyperbaric oxygen therapy improves functional disorders and prognosis of patients with traumatic brain injury
topic Discovery Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568788/
https://www.ncbi.nlm.nih.gov/pubmed/34546088
http://dx.doi.org/10.1089/wound.2018.0876
work_keys_str_mv AT luyin earlyintensifiedrehabilitationtrainingwithhyperbaricoxygentherapyimprovesfunctionaldisordersandprognosisofpatientswithtraumaticbraininjury
AT zhouxianshan earlyintensifiedrehabilitationtrainingwithhyperbaricoxygentherapyimprovesfunctionaldisordersandprognosisofpatientswithtraumaticbraininjury
AT chengjincheng earlyintensifiedrehabilitationtrainingwithhyperbaricoxygentherapyimprovesfunctionaldisordersandprognosisofpatientswithtraumaticbraininjury
AT maqing earlyintensifiedrehabilitationtrainingwithhyperbaricoxygentherapyimprovesfunctionaldisordersandprognosisofpatientswithtraumaticbraininjury