Is Myelodysplasia a Consequence of Normal Aging?

PURPOSE OF REVIEW: To review available data on the relationship of MDS and aging and to address the question if biological changes of (premature) aging are a prerequisite for the development of MDS. RECENT FINDINGS: Whereas the association of MDS with advanced age and some common biologic features o...

Descripción completa

Detalles Bibliográficos
Autores principales: Heibl, Sonja, Stauder, Reinhard, Pfeilstöcker, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Geriatric Oncology (L Balducci, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568861/
https://www.ncbi.nlm.nih.gov/pubmed/34735656
http://dx.doi.org/10.1007/s11912-021-01136-5
_version_ 1784594520941264896
author Heibl, Sonja
Stauder, Reinhard
Pfeilstöcker, Michael
author_facet Heibl, Sonja
Stauder, Reinhard
Pfeilstöcker, Michael
author_sort Heibl, Sonja
collection PubMed
description PURPOSE OF REVIEW: To review available data on the relationship of MDS and aging and to address the question if biological changes of (premature) aging are a prerequisite for the development of MDS. RECENT FINDINGS: Whereas the association of MDS with advanced age and some common biologic features of aging and MDS are well established, additional evidence for both, especially on the role of stem cells, the stem cell niche, and inflammation, has been recently described. SUMMARY: Biologically, many but not all drivers of aging also play a role in the development and propagation of MDS and vice versa. As a consequence, aging contributes to the development of MDS which can be seen as an interplay of clonal disease and normal and premature aging. The impact of aging may be different in specific MDS subtypes and risk groups.
format Online
Article
Text
id pubmed-8568861
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-85688612021-11-08 Is Myelodysplasia a Consequence of Normal Aging? Heibl, Sonja Stauder, Reinhard Pfeilstöcker, Michael Curr Oncol Rep Geriatric Oncology (L Balducci, Section Editor) PURPOSE OF REVIEW: To review available data on the relationship of MDS and aging and to address the question if biological changes of (premature) aging are a prerequisite for the development of MDS. RECENT FINDINGS: Whereas the association of MDS with advanced age and some common biologic features of aging and MDS are well established, additional evidence for both, especially on the role of stem cells, the stem cell niche, and inflammation, has been recently described. SUMMARY: Biologically, many but not all drivers of aging also play a role in the development and propagation of MDS and vice versa. As a consequence, aging contributes to the development of MDS which can be seen as an interplay of clonal disease and normal and premature aging. The impact of aging may be different in specific MDS subtypes and risk groups. Springer US 2021-11-04 2021 /pmc/articles/PMC8568861/ /pubmed/34735656 http://dx.doi.org/10.1007/s11912-021-01136-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Geriatric Oncology (L Balducci, Section Editor)
Heibl, Sonja
Stauder, Reinhard
Pfeilstöcker, Michael
Is Myelodysplasia a Consequence of Normal Aging?
title Is Myelodysplasia a Consequence of Normal Aging?
title_full Is Myelodysplasia a Consequence of Normal Aging?
title_fullStr Is Myelodysplasia a Consequence of Normal Aging?
title_full_unstemmed Is Myelodysplasia a Consequence of Normal Aging?
title_short Is Myelodysplasia a Consequence of Normal Aging?
title_sort is myelodysplasia a consequence of normal aging?
topic Geriatric Oncology (L Balducci, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568861/
https://www.ncbi.nlm.nih.gov/pubmed/34735656
http://dx.doi.org/10.1007/s11912-021-01136-5
work_keys_str_mv AT heiblsonja ismyelodysplasiaaconsequenceofnormalaging
AT stauderreinhard ismyelodysplasiaaconsequenceofnormalaging
AT pfeilstockermichael ismyelodysplasiaaconsequenceofnormalaging

Ejemplares similares