Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a progressive fatal neurodegenerative disease caused by loss of motor neurons and characterized neuropathologically in almost all cases by nuclear depletion and cytoplasmic aggregation of TDP-43, a nuclear RNA-binding protein (RBP). We identified ELAVL3 as one of the...

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Detalles Bibliográficos
Autores principales: Diaz-Garcia, Sandra, Ko, Vivian I., Vazquez-Sanchez, Sonia, Chia, Ruth, Arogundade, Olubankole Aladesuyi, Rodriguez, Maria J., Traynor, Bryan J., Cleveland, Don, Ravits, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568872/
https://www.ncbi.nlm.nih.gov/pubmed/34618203
http://dx.doi.org/10.1007/s00401-021-02374-4

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