A method to estimate probability of disease and vaccine efficacy from clinical trial immunogenicity data

Vaccine efficacy is often assessed by counting disease cases in a clinical trial. A new quantitative framework proposed here (“PoDBAY,” Probability of Disease Bayesian Analysis), estimates vaccine efficacy (and confidence interval) using immune response biomarker data collected shortly after vaccina...

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Detalles Bibliográficos
Autores principales: Dudášová, Julie, Laube, Regina, Valiathan, Chandni, Wiener, Matthew C., Gheyas, Ferdous, Fišer, Pavel, Ivanauskaite, Justina, Liu, Frank, Sachs, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568947/
https://www.ncbi.nlm.nih.gov/pubmed/34737322
http://dx.doi.org/10.1038/s41541-021-00377-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568947/
https://www.ncbi.nlm.nih.gov/pubmed/34737322
http://dx.doi.org/10.1038/s41541-021-00377-6

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