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Link between serum lipid signature and prognostic factors in COVID-19 patients
Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome. Sera fro...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568966/ https://www.ncbi.nlm.nih.gov/pubmed/34737330 http://dx.doi.org/10.1038/s41598-021-00755-z |
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author | Dei Cas, Michele Ottolenghi, Sara Morano, Camillo Rinaldo, Rocco Roda, Gabriella Chiumello, Davide Centanni, Stefano Samaja, Michele Paroni, Rita |
author_facet | Dei Cas, Michele Ottolenghi, Sara Morano, Camillo Rinaldo, Rocco Roda, Gabriella Chiumello, Davide Centanni, Stefano Samaja, Michele Paroni, Rita |
author_sort | Dei Cas, Michele |
collection | PubMed |
description | Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome. Sera from 49 COVID-19 patients were analyzed by untargeted lipidomics. Patients were clustered according to: inflammation (C-reactive protein), hypoxia (Horowitz Index), coagulation state (D-dimer), kidney function (creatinine) and age. COVID-19 patients exhibited remarkable and distinctive dyslipidemia for each prognostic factor associated with reduced defense against oxidative stress. When patients were clustered by outcome (7 days), a peculiar lipidome signature was detected with an overall increase of 29 lipid species, including—among others—four ceramide and three sulfatide species, univocally related to this analysis. Considering the lipids that were affected by all the prognostic factors, we found one sphingomyelin related to inflammation and viral infection of the respiratory tract and two sphingomyelins, that are independently related to patients' age, and they appear as candidate biomarkers to monitor disease progression and severity. Although preliminary and needing validation, this report pioneers the translation of lipidome signatures to link the effects of five critical clinical prognostic factors with the patients' outcomes. |
format | Online Article Text |
id | pubmed-8568966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85689662021-11-05 Link between serum lipid signature and prognostic factors in COVID-19 patients Dei Cas, Michele Ottolenghi, Sara Morano, Camillo Rinaldo, Rocco Roda, Gabriella Chiumello, Davide Centanni, Stefano Samaja, Michele Paroni, Rita Sci Rep Article Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome. Sera from 49 COVID-19 patients were analyzed by untargeted lipidomics. Patients were clustered according to: inflammation (C-reactive protein), hypoxia (Horowitz Index), coagulation state (D-dimer), kidney function (creatinine) and age. COVID-19 patients exhibited remarkable and distinctive dyslipidemia for each prognostic factor associated with reduced defense against oxidative stress. When patients were clustered by outcome (7 days), a peculiar lipidome signature was detected with an overall increase of 29 lipid species, including—among others—four ceramide and three sulfatide species, univocally related to this analysis. Considering the lipids that were affected by all the prognostic factors, we found one sphingomyelin related to inflammation and viral infection of the respiratory tract and two sphingomyelins, that are independently related to patients' age, and they appear as candidate biomarkers to monitor disease progression and severity. Although preliminary and needing validation, this report pioneers the translation of lipidome signatures to link the effects of five critical clinical prognostic factors with the patients' outcomes. Nature Publishing Group UK 2021-11-04 /pmc/articles/PMC8568966/ /pubmed/34737330 http://dx.doi.org/10.1038/s41598-021-00755-z Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Dei Cas, Michele Ottolenghi, Sara Morano, Camillo Rinaldo, Rocco Roda, Gabriella Chiumello, Davide Centanni, Stefano Samaja, Michele Paroni, Rita Link between serum lipid signature and prognostic factors in COVID-19 patients |
title | Link between serum lipid signature and prognostic factors in COVID-19 patients |
title_full | Link between serum lipid signature and prognostic factors in COVID-19 patients |
title_fullStr | Link between serum lipid signature and prognostic factors in COVID-19 patients |
title_full_unstemmed | Link between serum lipid signature and prognostic factors in COVID-19 patients |
title_short | Link between serum lipid signature and prognostic factors in COVID-19 patients |
title_sort | link between serum lipid signature and prognostic factors in covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568966/ https://www.ncbi.nlm.nih.gov/pubmed/34737330 http://dx.doi.org/10.1038/s41598-021-00755-z |
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