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Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren

The hunger hormone ghrelin activates the ghrelin receptor GHSR to stimulate food intake and growth hormone secretion and regulate reward signaling. Acylation of ghrelin at Ser3 is required for its agonistic action on GHSR. Synthetic agonists of GHSR are under clinical evaluation for disorders relate...

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Detalles Bibliográficos
Autores principales:	Liu, Heng, Sun, Dapeng, Myasnikov, Alexander, Damian, Marjorie, Baneres, Jean-Louis, Sun, Ji, Zhang, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568970/ https://www.ncbi.nlm.nih.gov/pubmed/34737341 http://dx.doi.org/10.1038/s41467-021-26735-5

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