Cargando…

Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of childbearing age and research findings have revealed a potential association between PCOS and renal dysfunction. This study aimed to investigate renal dysfunction that might be associated with PCOS in rats and to...

Descripción completa

Detalles Bibliográficos
Autores principales: Alahmadi, Ahlam A., Alahmadi, Bassam A., Wahman, Lobna F., El-Shitany, Nagla A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568996/
https://www.ncbi.nlm.nih.gov/pubmed/34764746
http://dx.doi.org/10.1016/j.sjbs.2021.06.066
_version_ 1784594553442926592
author Alahmadi, Ahlam A.
Alahmadi, Bassam A.
Wahman, Lobna F.
El-Shitany, Nagla A.
author_facet Alahmadi, Ahlam A.
Alahmadi, Bassam A.
Wahman, Lobna F.
El-Shitany, Nagla A.
author_sort Alahmadi, Ahlam A.
collection PubMed
description Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of childbearing age and research findings have revealed a potential association between PCOS and renal dysfunction. This study aimed to investigate renal dysfunction that might be associated with PCOS in rats and to evaluate the potential protective effect of chamomile against PCOS complicated by kidney damage. A rat model of PCOS was induced by injecting estradiol valerate (0.2 mg/rat × 2) into adult virgin female rats. Rats were treated with either ethyl alcohol extract of chamomile flower (75 mg/kg/day) or metformin (Met) (500 mg/kg/day). Induction of PCOS was associated with increased relative right kidney weight percentage and increased serum levels of urea, lipid peroxide product, and testosterone. PCOS was also associated with increased p53 expression in kidney glomeruli and medullary tubules with decreased Bcl2 expression in kidney glomeruli. Administration of chamomile extract significantly decreased levels of serum urea, testosterone, and lipid peroxide product, and p53 expression in kidney glomeruli and tubules. The extract significantly increased levels of antioxidant markers levels (reduced glutathione, catalase, and superoxide dismutase) and the expression of the anti-apoptotic gene Bcl2. Conversely, administration of Met did not improve serum levels of urea. Met also exerted no pronounced effect on p53 gene expression. The results of this study highlight the importance of monitoring kidney function in patients with PCOS and investigating the associated underlying mechanism. Chamomile extract was found to ameliorate kidney damage associated with PCOS through antioxidant, testosterone-lowering, and anti-apoptotic mechanisms.
format Online
Article
Text
id pubmed-8568996
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-85689962021-11-10 Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome Alahmadi, Ahlam A. Alahmadi, Bassam A. Wahman, Lobna F. El-Shitany, Nagla A. Saudi J Biol Sci Original Article Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of childbearing age and research findings have revealed a potential association between PCOS and renal dysfunction. This study aimed to investigate renal dysfunction that might be associated with PCOS in rats and to evaluate the potential protective effect of chamomile against PCOS complicated by kidney damage. A rat model of PCOS was induced by injecting estradiol valerate (0.2 mg/rat × 2) into adult virgin female rats. Rats were treated with either ethyl alcohol extract of chamomile flower (75 mg/kg/day) or metformin (Met) (500 mg/kg/day). Induction of PCOS was associated with increased relative right kidney weight percentage and increased serum levels of urea, lipid peroxide product, and testosterone. PCOS was also associated with increased p53 expression in kidney glomeruli and medullary tubules with decreased Bcl2 expression in kidney glomeruli. Administration of chamomile extract significantly decreased levels of serum urea, testosterone, and lipid peroxide product, and p53 expression in kidney glomeruli and tubules. The extract significantly increased levels of antioxidant markers levels (reduced glutathione, catalase, and superoxide dismutase) and the expression of the anti-apoptotic gene Bcl2. Conversely, administration of Met did not improve serum levels of urea. Met also exerted no pronounced effect on p53 gene expression. The results of this study highlight the importance of monitoring kidney function in patients with PCOS and investigating the associated underlying mechanism. Chamomile extract was found to ameliorate kidney damage associated with PCOS through antioxidant, testosterone-lowering, and anti-apoptotic mechanisms. Elsevier 2021-11 2021-06-30 /pmc/articles/PMC8568996/ /pubmed/34764746 http://dx.doi.org/10.1016/j.sjbs.2021.06.066 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Alahmadi, Ahlam A.
Alahmadi, Bassam A.
Wahman, Lobna F.
El-Shitany, Nagla A.
Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome
title Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome
title_full Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome
title_fullStr Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome
title_full_unstemmed Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome
title_short Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome
title_sort chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568996/
https://www.ncbi.nlm.nih.gov/pubmed/34764746
http://dx.doi.org/10.1016/j.sjbs.2021.06.066
work_keys_str_mv AT alahmadiahlama chamomileflowerextractamelioratesbiochemicalandhistologicalkidneydysfunctionassociatedwithpolycysticovarysyndrome
AT alahmadibassama chamomileflowerextractamelioratesbiochemicalandhistologicalkidneydysfunctionassociatedwithpolycysticovarysyndrome
AT wahmanlobnaf chamomileflowerextractamelioratesbiochemicalandhistologicalkidneydysfunctionassociatedwithpolycysticovarysyndrome
AT elshitanynaglaa chamomileflowerextractamelioratesbiochemicalandhistologicalkidneydysfunctionassociatedwithpolycysticovarysyndrome